- 著者
- Kazuo Nakanishi Yasukazu Hijikata Kazuya Uchino Seiya Watanabe Kosuke Misaki Hideaki Iba
- 出版者
- The Japanese Society for Spine Surgery and Related Research
- 雑誌
- Spine Surgery and Related Research (ISSN:2432261X)
- 巻号頁・発行日
- vol.6, no.1, pp.26-30, 2022-01-27 (Released:2022-01-27)
- 参考文献数
- 22
- 被引用文献数
- 1
Introduction: There is a growing momentum for the collaboration between multiple disciplines for the prevention and treatment of skeletal-related events (SREs) in patients with metastatic spinal tumors. However, the effectiveness of multidisciplinary approaches remains unclear. Hence, we conducted an exploratory study to examine the impact of liaison treatment for metastatic spinal tumor (LMST) on the prevention of SREs among patients with a metastatic spinal tumor.Methods: This study was an exploratory interrupted time series conducted in a single medical center. Overall, 1,043 patients with a metastatic spinal tumor diagnosed between January 2011 and December 2020 were included. The LMST was implemented in January 2014. The LMST team consisted of the orthopedic surgery, thoracic surgery, breast and thyroid surgery, clinical oncology, urology, and radiology departments. Monthly joint conferences were held for patients with spinal instability, and the incidence of SRE was measured at 6-month intervals.Results: Throughout the study period, we identified 66 SRE incidences. After the implementation of the LMST, a level change of −5.2% (95% confidence interval [CI]: −11.7 to 1.3, p = 0.11) was observed. Subsequently, a post-implementation trend change of −0.3% (95% CI: −2.0 to 1.5, p = 0.75) beyond the baseline was noted.Conclusions: We suggest both immediate and gradual effects of the introduction of the LMST on deterring the development of SREs. Our results support the global trend of introducing a multidisciplinary approach for the treatment of metastatic spinal tumors.
- 著者
- Kaisei Sato Hikaru Okubo Shouhei Kawada Seiya Watanabe Shinya Sasaki
- 出版者
- Japanese Society of Tribologists
- 雑誌
- Tribology Online (ISSN:18812198)
- 巻号頁・発行日
- vol.16, no.3, pp.178-191, 2021-09-30 (Released:2021-09-30)
- 参考文献数
- 66
- 被引用文献数
- 5
Ionic liquids (ILs) are being considered as novel lubricant additives to improve the friction and anti-wear characteristics of sliding surfaces. Because ILs consist of only cations and anions, their physical and chemical properties can be easily tailored by modifying their combination. These features enable to design of specific ILs for a given tribological system. However, there are few reports on the effect of ILs used as lubricant additives on the friction and anti-wear characteristics of sliding surfaces. Moreover, it is necessary to investigate the synergism between ILs and other lubricant additives to achieve high practical efficiency. Therefore, in this study, two ILs with different cations but similar anions were used in combination with an anti-wear additive, zinc dialkyldithiophosphate (ZDDP), and the resultant wear and friction characteristics of the worn surfaces were analyzed. We found that the tribological performance under steel/steel sliding conditions was dependent on the chemical composition of the ILs. In addition, mixed ZDDP and IL solutions exhibited lower friction and wear when compared to ZDDP alone. It is considered that the excellent lubrication and frictional performance observed with the mixed lubricant solutions is due to the formation of tribofilms comprising of ZDDP and IL on the sliding surface.