- 著者
- Sheng LI Yuya AKITA Tatsuya KAWAHARA
- 出版者
- 一般社団法人 電子情報通信学会
- 雑誌
- IEICE Transactions on Information and Systems (ISSN:09168532)
- 巻号頁・発行日
- vol.E98.D, no.8, pp.1545-1552, 2015-08-01 (Released:2015-08-01)
- 参考文献数
- 29
The paper addresses a scheme of lightly supervised training of an acoustic model, which exploits a large amount of data with closed caption texts but not faithful transcripts. In the proposed scheme, a sequence of the closed caption text and that of the ASR hypothesis by the baseline system are aligned. Then, a set of dedicated classifiers is designed and trained to select the correct one among them or reject both. It is demonstrated that the classifiers can effectively filter the usable data for acoustic model training. The scheme realizes automatic training of the acoustic model with an increased amount of data. A significant improvement in the ASR accuracy is achieved from the baseline system and also in comparison with the conventional method of lightly supervised training based on simple matching.
- 著者
- Guo-Sheng Li Xu-Han Liu Hua Zhu Lan Huang Ya-Li Liu Chun-Mei Ma Chuan Qin
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.34, no.5, pp.644-654, 2011-05-01 (Released:2011-05-01)
- 参考文献数
- 41
- 被引用文献数
- 10 28
The diabetic “lipotoxicity” hypothesis presents that fat-induced visceral white adipose tissue insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Berberine, a hypolipidemic agent, has been reported to have antidiabetic activities. The molecular mechanisms for this property are, however, not well clarified. Therefore in this study type 2 diabetic hamsters were induced by high-fat diet with low-dose streptozotocin. Then, we investigated the gene expression alterations and explored the molecular mechanisms underlying the therapeutic effect of berberine on fat-induced visceral white adipose tissue insulin resistance in diabetic hamsters by microarray analysis followed by real-time reverse transcription-polymerase chain reaction (RT-PCR) confirmation. Type 2 diabetic hamsters exhibited hyperglycemia and relative hyperinsulinemia, glucose intolerance, insulin resistance, intra-adipocyte lipid accumulation, significant increase in body weight and visceral white adipose tissue weight, abnormal serum adipokines levels, and deleterious dyslipidemia. Furthermore, they had increased sterol regulatory element-binding proteins (SREBPs) expression and decreased liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) expression in visceral white adipose tissue. After 9-week berberine treatment, fat-induced insulin resistance and diabetic phenotype in type 2 diabetic hamsters were significantly improved. Compared with diabetic hamsters, expression of LXRs and PPARs significantly increased and SREBPs significantly decreased in visceral white adipose tissue from berberine-treated diabetic hamsters. These results suggest that altered visceral white adipose tissue LXRs, PPARs, and SREBPs transcriptional programs are involved in the therapeutic mechanisms of berberine on fat-induced visceral white adipose tissue insulin resistance in type 2 diabetic hamsters.