著者
Yu-Ming Chi Motoyuki Nakamura Toyokichi Yoshizawa Xi-Ying Zhao Wen-Mei Yan Fumio Hashimoto Junei Kinjo Toshihiro Nohara Shinobu Sakurada
出版者
公益社団法人日本薬学会
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.28, no.10, pp.1989-1991, 2005 (Released:2005-10-01)
参考文献数
18
被引用文献数
14 17

To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.