- 著者
- Kraisiri KHIDKHAN Hazuki MIZUKAWA Yoshinori IKENAKA Shouta M. M. NAKAYAMA Kei NOMIYAMA Nozomu YOKOYAMA Osamu ICHII Mitsuyoshi TAKIGUCHI Shinsuke TANABE Mayumi ISHIZUKA
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.20-0140, (Released:2020-05-21)
- 被引用文献数
- 2
The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1–CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers (PBDEs) in cat.
- 著者
- Hiroshi Hoshino Shouichi Fujita Yoko Goto Takeomi Isono Tsuyoshi Ishinazaka Yasunori Sakurai Hisato Iwata Akio Kazusaka Mayumi Ishizuka Shinsuke Tanabe
- 出版者
- The Japanese Society of Environmental Toxicology
- 雑誌
- 環境毒性学会誌 (ISSN:13440667)
- 巻号頁・発行日
- vol.6, no.1, pp.1-10, 2003 (Released:2010-07-01)
- 参考文献数
- 23
o clarify the levels of organochlorine compounds (OCs) and the metabolism of OCs in the body of Steller sea lion Eumetopias jubatus migrating along the coast of Hokkaido, OCs in the sea lion's blubbers for each age, sex and reproductive status were determined by gas chromatography linked to ion trap mass spectrometer. In sea lions, the compounds accumulated in the highest concentrations are DDT and its metabolites (DDTs) suggesting these animals are still exposed to DDTs from the surrounding land. The levels of DDTs and polychlorinated biphenyls (PCBs) in sea lions may cause small effects such as the induction of drug metabolizing enzymes. The concentrations of DDTs, PCBs, hexachlorocyclohexanes and chlordanes in the old female sea lions were lower than those in the males and young females. This is most likely due to the loss of these compounds during nursing. In addition, the concentrations of each compound differed in the degree of difference between the young and the old females. This result may reflect ecological and physiological difference between the young and the old females. The proportions of tetrachlorinated biphenyl concentrations with vicinal hydrogen atoms in para- and meta- positions to total tetrachlorinated biphenyl concentrations were found to be higher in older animals implying low “phenobarbital inducible type” enzyme activity.