著者

Sho ENDO Jun SONODA Motoyuki SATO Takafumi AOKI

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E94-D, no.12, pp.2338-2344, 2011-12-01

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Finite difference time domain (FDTD) method has been accelerated on the Cell Broadband Engine (Cell B.E.). However the problem has arisen that speedup is limited by the bandwidth of the main memory on large-scale analysis. As described in this paper, we propose a novel algorithm and implement FDTD using it. We compared the novel algorithm with results obtained using region segmentation, thereby demonstrating that the proposed algorithm has shorter calculation time than that provided by region segmentation.

著者

Masanori Tamaki Kazutoshi Miyashita Aika Hagiwara Shu Wakino Hiroyuki Inoue Kentaro Fujii Chikako Fujii Sho Endo Asuka Uto Masanori Mitsuishi Masaaki Sato Toshio Doi Hiroshi Itoh

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.64, no.Suppl., pp.S47-S51, 2017 (Released:2017-06-24)

参考文献数

14

被引用文献数

25

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Chronic kidney disease (CKD) impairs physical performance in humans, which leads to a risk of all-cause mortality. In our previous study, we demonstrated that a reduction in muscle mitochondria rather than muscle mass was a major cause of physical decline in 5/6 nephrectomized CKD model mice. Because ghrelin administration has been reported to enhance oxygen utilization in skeletal muscle, we examined the usefulness of ghrelin for a recovery of physical decline in 5/6 nephrectomized C57Bl/6 mice, focusing on the epigenetic modification of peroxisome proliferator activated receptor gamma coactivator-1α (PGC-1α), a master regulator of mitochondrial biogenesis. The mice were intraperitoneally administered acylated ghrelin (0.1 nmol/gBW; three times per week) for a month. Muscle strength and exercise endurance were measured by using a dynamometer and treadmill, respectively. Mitochondrial DNA copy number was determined by quantitative PCR. The methylation levels of the cytosine residue at 260 base pairs upstream of the translation initiation point (C-260) of PGC-1α, which has been demonstrated to decrease the expression, was evaluated by methylation-specific PCR and bisulfite genomic sequencing methods after the ghrelin administration. Ghrelin administration improved both muscle strength and exercise endurance in the mice and was associated with an increase in muscle mass and muscle mitochondrial content. Ghrelin administration decreased the methylation ratio of C-260 of PGC-1α in the skeletal muscle and increased the expression. Therefore, ghrelin administration effectively reduced the physical decline in 5/6 nephrectomized mice and was accompanied with an increased mitochondrial content through de-methylation of the promoter region of PGC-1α in the muscle.