- 著者
- Shu ZHANG Waheed MIRAN Divya NARADASU Siyi GUO Akihiro OKAMOTO
- 出版者
- The Electrochemical Society of Japan
- 雑誌
- Electrochemistry (ISSN:13443542)
- 巻号頁・発行日
- pp.20-00021, (Released:2020-04-21)
- 参考文献数
- 34
- 被引用文献数
- 9
Microbial extracellular electron transfer (EET) in diverse environments has gained increasing attention. However, the EET capability of oral pathogens and associated mechanisms has been scarcely studied. Here, our results suggest that the Capnocytophaga ochracea, an etiological human pathogen showed current production and demonstrated a rate enhancement of electron transport at a high cell-density. C. ochracea produced ∼10-fold more current at an OD600 of 0.5 associated with twice a higher glucose consumption rate per cell, compared to 0.1, measured in a three-electrode electrochemical system by single-potential amperometry at +0.2 V (vs Ag/AgCl [sat. KCl]). During current production, the accumulation of the redox molecules on the electrode was observed at high OD600 compared to low OD600. Apart from cell released redox active product, externally added redox active additives enhanced the electron transport, suggesting the EET capability of C. ochracea via electron mediator. A higher metabolic activity via single-cell assay (based on anabolic incorporation of 15NH4+) in cells that did not attach to the electrode strongly suggests the EET rate enhancement through an electron mediator. As bacterial populations play a role in the pathogenesis of human infections such as periodontitis, our results suggest that population-induced EET mechanisms may facilitate in-vivo colonization of C. ochracea.
- 著者
- Chi Cai Wei Hua Li-Gang Ding Jing Wang Ke-Ping Chen Xin-Wei Yang Zhi-Min Liu Shu Zhang
- 出版者
- 日本循環器学会
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.78, no.12, pp.2899-2907, 2014-11-25 (Released:2014-11-25)
- 参考文献数
- 24
- 被引用文献数
- 8 20
Background:The effect of adiposity on response to cardiac resynchronization therapy (CRT) and long-term outcome in patients undergoing CRT has not been previously reported. This study assessed the impact of baseline body mass index (BMI) on cardiac reverse remodeling and prognosis following CRT.Methods and Results:A total of 247 CRT patients were included and divided into 4 groups according to baseline BMI. During 6-month follow-up, overweight and obese patients (BMI, 24–28 kg/m2, ≥28 kg/m2, respectively) were inclined to have better clinical and echocardiographic improvements (P<0.05) as well as higher response rate (P<0.001) than underweight and normal weight patients (BMI, <18.5 kg/m2, 18.5–24 kg/m2, respectively). During long-term follow-up, overweight and obese patients had lower all-cause mortality (P=0.015) and combined endpoint of death or HF hospitalizations (P=0.001) than underweight and normal weight patients. Compared with normal weight patients, underweight patients had a 2.29-fold increase in risk of combined endpoint events whereas overweight and obese patients had a reduction in the risk of death (66% and 58%, respectively) and combined endpoint events (52% and 38%, respectively).Conclusions:Patients with obesity and overweight derived more benefit from CRT. Higher BMI was independently associated with better clinical outcome in CRT patients. (Circ J 2014; 78: 2899–2907)