- 著者
- Sataporn Direkbusarakom Hironobu Kinoshita Chettupon Pooljun Sudarat Saeng-ngern Suwit Wuthisuthimethavee
- 出版者
- The Japanese Society of Fish Pathology
- 雑誌
- 魚病研究 (ISSN:0388788X)
- 巻号頁・発行日
- vol.55, no.4, pp.125-131, 2021-01-15 (Released:2021-01-21)
- 参考文献数
- 22
- 被引用文献数
- 1 3
5-aminolevulinic acid (5-ALA) is an endogenous non-protein amino acid that is widely used in medicine, pharmacy products, agriculture, and aquaculture. In this study, the aim is to investigate the effects of 5-ALA on feeding Pacific white shrimp (Litopenaeus vannamei) with a diet supplemented with 5-ALA on their growth performance, immune responses, and resistance to acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio paraheamolyticus. Shrimp were fed with different diets, including a commercial diet (control) and diets supplemented with 15 ppm (ALA15) and 30 ppm (ALA30) of 5-ALA for 15 and 30 days before bacteria challenge. Anti-lipopolysaccharide factor, crustin, and penaeidin3 immune genes had significantly increased expression level after 15 and 30 days of feeding with 5-ALA. The mortality rate of L. vannamei fed with 5-ALA for 15 and 30 days significantly decreased after V. parahaemolyticus infection. These results indicated that the diet supplemented with 5-ALA enhanced the innate immune response and consequently shrimp's pathogen tolerance. Thus, 5-ALA can be used as immunostimulant additive for Pacific white shrimp cultivation.