- 著者
- TSUYOSHI SUZUKI TATSUO KAWAMOTO DAISUKE YAMADA RYOUHEI KITAMURA NAOKO TOMINAGA HIROKI FUKUOKA KEIJI MORIYAMA
- 出版者
- THE JAPANESE SOCIETY FOR JAW DEFORMITIES
- 雑誌
- The Japanese Journal of Jaw Deformities (ISSN:09167048)
- 巻号頁・発行日
- vol.20, no.3, pp.220-227, 2010-08-15 (Released:2012-03-16)
- 参考文献数
- 28
- 被引用文献数
- 5
The present study conducted a statistical survey of 1118 patients with jaw deformity who underwent surgical orthodontic treatment in the Section of Maxillofacial Orthognathics, Department of Orthodontics, Tokyo Medical and Dental University from 1980 to 2009.The results were as follows:1. There were 442 male and 676 female patients (ratio 1:1.5).2. The mean age at operation of all patients was 24.2 years old. The mean age has tended to increase in recent years.3. The most common condition was mandibular prognathism without other deformities of the jaw, accounting for 47.3% of the patients. Next was mandibular prognathism with asymmetry, accounting for 20.4%, and then mandibular prognathism with open bite, accounting for 14.1%.4. The most frequently used surgical procedure was sagittal split ramus osteotomy (SSRO), accounting for 64.0%. The combination of Le Fort I osteotomy and SSRO accounted for 21.0%.5. For bone fixation after SSRO, wire fixation, which used to be the most common method, has been almost completely replaced by screw or mini-plate fixation in recent years.
- 著者
- Erina Ikeda Tetsuya Goto Kaori Gunjigake Kayoko Kuroishi Masae Ueda Shinji Kataoka Takashi Toyono Mitsushiro Nakatomi Yuji Seta Chiaki Kitamura Tatsuji Nishihara Tatsuo Kawamoto
- 出版者
- 日本組織細胞化学会
- 雑誌
- ACTA HISTOCHEMICA ET CYTOCHEMICA (ISSN:00445991)
- 巻号頁・発行日
- pp.15022, (Released:2016-02-10)
- 被引用文献数
- 5
Several theories have been proposed regarding pain transmission mechanisms in tooth. However, the exact signaling mechanism from odontoblasts to pulp nerves remains to be clarified. Recently, ATP-associated pain transmission has been reported, but it is unclear whether ATP is involved in tooth pain transmission. In the present study, we focused on the vesicular nucleotide transporter (VNUT), a transporter of ATP into vesicles, and examined whether VNUT was involved in ATP release from odontoblasts. We examined the expression of VNUT in rat pulp by RT-PCR and immunostaining. ATP release from cultured odontoblast-like cells with heat stimulation was evaluated using ATP luciferase methods. VNUT was expressed in pulp tissue, and the distribution of VNUT-immunopositive vesicles was confirmed in odontoblasts. In odontoblasts, some VNUT-immunopositive vesicles were colocalized with membrane fusion proteins. Additionally P2X3, an ATP receptor, immunopositive axons were distributed between odontoblasts. The ATP release by thermal stimulation from odontoblast-like cells was inhibited by the addition of siRNA for VNUT. These findings suggest that cytosolic ATP is transported by VNUT and that the ATP in the vesicles is then released from odontoblasts to ATP receptors on axons. ATP vesicle transport in odontoblasts seems to be a key mechanism for signal transduction from odontoblasts to axons in the pulp.