著者

MASAAKI SAKURAI JUN KOHNO MAKI NISHIO KOZO YAMAMOTO TORU OKUDA KIMIO KAWANO NORIYUKI NAKANISHI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.54, no.8, pp.628-634, 2001-08-25 (Released:2008-09-19)

参考文献数

12

被引用文献数

10 9

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A new transcriptional up-regulator designated TMC-205 was discovered from the fermentation broth of an unidentified fungal strain TC 1630 by using an SV40 promoterluciferase reporter assay. Based on spectroscopic analyses, its structure was determined to be (E)-6-(3-methyl-1, 3-butadienyl)-1H-indole-3-carboxylic acid. Expression of the luciferase activity was activated ca. 2-, 4-, and 6-fold by 1, 10, and 100μM TMC-205, respectively. TMC-205 activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region.