- 著者
- Jeong Hui Kim Ryosuke Kikuchi Atsuo Suzuki Rika Watarai Kaori Goto Yui Okumura Tadashi Matsushita
- 出版者
- Japanese Society of Laboratory Medicine
- 雑誌
- Laboratory Medicine International (ISSN:24368660)
- 巻号頁・発行日
- vol.2, no.3, pp.60-66, 2023 (Released:2023-12-29)
- 参考文献数
- 24
The immune system produces antibodies following SARS-CoV-2 infection and vaccination. However, we lack comprehensive information about the humoral responses after infection and vaccination, which are similar but might differ in type or amount of produced antibodies. Therefore, we compared different types and amounts of antibodies produced by the immune system in response to infection versus those produced by BNT162b2 (Pfizer/BioNTech) vaccines. Our findings indicated that naturally infected individuals had 14-fold higher anti-SARS-CoV-2 spike protein (anti-S) and 41-fold higher anti-SARS-CoV-2 receptor-binding domain of the viral spike protein (anti-RBD) IgM titers than SARS-CoV-2-naïve vaccinees. Remarkably, naturally infected individuals maintained high levels of IgM antibody titers up to six weeks after symptom onset. A significantly rapid increase in anti-S IgG titers in primary infection was observed, eventually reaching a level similar to that in people who had third booster vaccination. This study revealed the characteristics of the target antigen and immunoglobulin isotypes after natural SARS-CoV-2 infection and COVID-19 vaccination.
- 著者
- Akihito Tanaka Hideki Ishii Yosuke Tatami Yohei Shibata Naohiro Osugi Tomoyuki Ota Yoshihiro Kawamura Susumu Suzuki Yoshimasa Nagao Tadashi Matsushita Toyoaki Murohara
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.55, no.4, pp.333-337, 2016 (Released:2016-02-15)
- 参考文献数
- 23
- 被引用文献数
- 5
Objective Heparin is not recommended to be administered during the interruption of antiplatelet therapy for non-cardiac surgery. However, there are insufficient data to determine the value. The purpose of the present study was to evaluate the clinical results of the administration of unfractionated heparin during the interruption of antiplatelet therapy in non-cardiac surgery patients who had previously undergone drug-eluting stent (DES) implantation. Methods We retrospectively identified 210 elective non-cardiac surgical procedures that were performed with the administration of unfractionated heparin during interruption of all antiplatelet therapies in patients who had previously undergone DES implantation. Heparin was administered during the perioperative period in accordance with the local practice guideline at out institution. We examined the clinical outcomes within 30 days of surgery. Results The mean number of implanted DESs was 2.1±1.3. No major adverse cardiac events (including cardiac death, definite stent thrombosis, and non-fatal myocardial infarction) occurred in any of the 210 cases within 30 days of surgery. Four of the 210 cases (1.9%) required reoperation for bleeding within 30 days of surgery. Conclusion Our data showed the potential for the perioperative management with unfractionated heparin administration in Japanese patients who had previously undergone DES implantation who required non-cardiac surgery with the interruption of all antiplatelet therapies.