著者
Jeong Hui Kim Ryosuke Kikuchi Atsuo Suzuki Rika Watarai Kaori Goto Yui Okumura Tadashi Matsushita
出版者
Japanese Society of Laboratory Medicine
雑誌
Laboratory Medicine International (ISSN:24368660)
巻号頁・発行日
vol.2, no.3, pp.60-66, 2023 (Released:2023-12-29)
参考文献数
24

The immune system produces antibodies following SARS-CoV-2 infection and vaccination. However, we lack comprehensive information about the humoral responses after infection and vaccination, which are similar but might differ in type or amount of produced antibodies. Therefore, we compared different types and amounts of antibodies produced by the immune system in response to infection versus those produced by BNT162b2 (Pfizer/BioNTech) vaccines. Our findings indicated that naturally infected individuals had 14-fold higher anti-SARS-CoV-2 spike protein (anti-S) and 41-fold higher anti-SARS-CoV-2 receptor-binding domain of the viral spike protein (anti-RBD) IgM titers than SARS-CoV-2-naïve vaccinees. Remarkably, naturally infected individuals maintained high levels of IgM antibody titers up to six weeks after symptom onset. A significantly rapid increase in anti-S IgG titers in primary infection was observed, eventually reaching a level similar to that in people who had third booster vaccination. This study revealed the characteristics of the target antigen and immunoglobulin isotypes after natural SARS-CoV-2 infection and COVID-19 vaccination.

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SARS-CoV-2感染に反応して免疫系が産生する抗体と、BNT162b2(Pfizer/BioNTech)ワクチンによって産生される抗体の種類と量を比較した論文です☑️SARS-CoV-2自然感染およびCOVID-19ワクチン接種後の標的抗原と免疫グロブリンアイソタイプの特徴が明らかになりました

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