著者
Keisuke Matsuo Takashi Ishiguro Takatomo Najama Yoshihiko Shimizu Yasuhito Kobayashi Makoto Mutou
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.58, no.16, pp.2367-2372, 2019-08-15 (Released:2019-08-15)
参考文献数
19
被引用文献数
15

A 62-year-old man presented to our hospital for the further evaluation and treatment of his back pain, general fatigue, and dyspnea, which had developed 4 days after the 29th administration of nivolumab to treat his lung cancer. Based on his clinical history, elevated serum cardiac enzyme values, and cardiac magnetic resonance (CMR) imaging and myocardial biopsy findings, he was diagnosed with myocarditis induced by nivolumab. Corticosteroid therapy improved his condition, and CMR performed on hospital day 11 also showed remarkable improvement. Although nivolumab-induced myocarditis is rare, cardiologists should consider it when encountering patients treated with such a drug for malignant disease.
著者
Takashi Ishiguro Yasuhito Kobayashi Ryuji Uozumi Naomi Takata Yotaro Takaku Naho Kagiyama Tetsu Kanauchi Yoshihiko Shimizu Noboru Takayanagi
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.58, no.24, pp.3509-3519, 2019-12-15 (Released:2019-12-15)
参考文献数
32
被引用文献数
15 29

Objective The clinical characteristics and chest imaging findings of viral pneumonia and several interstitial lung diseases (ILDs) overlap, and viral pneumonia may be underrecognized and misdiagnosed as certain ILDs. To clarify the frequency of viral pneumonia among patients with acute progressive clinical courses that required a differential diagnosis between ILDs and pneumonia, and to determine the most frequent ILDs misdiagnosed in cases of viral pneumonia. Patients and Methods We retrospectively analyzed patients hospitalized from 2010 to 2017 with an acute clinical course (≤30 days) who underwent bronchoalveolar lavage (BAL) for the differential diagnosis of infection and ILDs. We performed a multiplex PCR for respiratory viruses using the patients' preserved BAL fluid. The final diagnosis was made by a multidisciplinary approach and after considering the PCR results. The diagnosis at discharge was compared to the final diagnosis. Results Among the 109 patients, 53 were diagnosed with viral pneumonia. Viral pneumonia and other diseases showed some differences in symptoms and laboratory data; however, the differences were small or overlapped. Viral pneumonia was misdiagnosed on discharge as acute fibrinous organizing pneumonia, cryptogenic organizing pneumonia, or chronic eosinophilic pneumonia (AFOP/COP/CEP) (n=22), acute interstitial pneumonia (n=5), connective tissue disease-related ILDs (n=3), unclassifiable interstitial pneumonia (n=2), drug-induced ILD (n=1), and pneumonia (n=20). Conclusion Approximately half of the patients who underwent BAL had viral pneumonia. The most common ILD-related misdiagnoses were AFOP/COP/CEP. Differences in symptoms and laboratory findings between viral pneumonia and other diseases were small, and viral pneumonia should be included in the differential diagnosis when physicians encounter cases in which the abovementioned ILDs are suspected.
著者
Masatoshi NAKAMURA Masato INAGI Kazuya TANIGAWA Tetsuo HIRONAKA Masayuki SATO Takashi ISHIGURO
出版者
一般社団法人 電子情報通信学会
雑誌
IEICE Transactions on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E95.D, no.2, pp.324-334, 2012-02-01 (Released:2012-02-01)
参考文献数
15

In this paper, we propose a placement and routing method for a new memory-based programmable logic device (MPLD) and confirm its capability by placing and routing benchmark circuits. An MPLD consists of multiple-output look-up tables (MLUTs) that can be used as logic and/or routing elements, whereas field programmable gate arrays (FPGAs) consist of LUTs (logic elements) and switch blocks (routing elements). MPLDs contain logic circuits more efficiently than FPGAs because of their flexibility and area efficiency. However, directly applying the existing placement and routing algorithms of FPGAs to MPLDs overcrowds the placed logic cells and causes a shortage of routing domains between logic cells. Our simulated annealing-based method considers the detailed wire congestion and nearness between logic cells based on the cost function and reserves the area for routing. In the experiments, our method reduced wire congestion and successfully placed and routed 27 out of 31 circuits, 13 of which could not be placed or routed using the versatile place and route tool (VPR), a well-known method for FPGAs.