- 著者
- Junya Hashizume Norihide Higuchi Kayoko Sato Yukinobu Kodama Noriko Matsunaga Toshiaki Sakamoto Kentaro Yamaguchi Tadahiro Nakamura Takashi Kitahara Hitoshi Sasaki
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.39, no.4, pp.611-614, 2016-04-01 (Released:2016-04-01)
- 参考文献数
- 21
Antiemetic prophylaxis with aprepitant, a 5-hydroxytryptamine3 (5-HT3) receptor antagonist and dexamethasone is recommended for patients receiving intravenous cisplatin chemotherapy. Whether the same antiemetic regime is superior for hepatic transcatheter arterial infusion chemotherapy with cisplatin (CDDP-TAI) is unknown. We conducted a retrospective study of antiemetic prophylaxis protection against chemotherapy-induced nausea and vomiting (CINV) in CDDP-TAI at Nagasaki University Hospital. The rate of complete response (CR) to antiemetics in the acute (<24 h) and delayed phases (24–120 h) was measured. Twenty-four patients were treated with a 5-HT3 receptor antagonist (granisetron or azasetron) and dexamethasone on the day of chemotherapy (day 1 only). There was a significant difference between the CR rates in the acute and delayed phases, 91.6, and 69.7%, respectively. Combination of a 5-HT3 antagonist and dexamethasone on day 1 is effective against acute CINV, but not delayed CINV during CDDP-TAI. These results may help guide the management of nausea and vomiting during CDDP-TAI to achieve better tolerance and compliance for fewer interventions and increased favorable therapeutic outcomes.
- 著者
- Takashi Kitahara Nao Koyama Junichi Matsuda Yuko Aoyama Yoichi Hirakata Shimeru Kamihira Shigeru Kohno Mikiro Nakashima Hitoshi Sasaki
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.27, no.9, pp.1321-1326, 2004 (Released:2004-09-01)
- 参考文献数
- 36
- 被引用文献数
- 78 92
The objective of this study was to investigate the antimicrobial activities of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus (MRSA). The antimicrobial activity of saturated fatty acids and fatty amines was determined by oxygen meters with multi-channels and disposable oxygen electrode sensors (DOX-96). Lauric acid, the most effective among the saturated fatty acids, showed antimicrobial activity at 400 μg/ml against methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA. The minimal inhibitory concentration (MIC) of fatty amines depended on each hydrophobic chain length. The MIC of myristylamine was 1.56 μg/ml; most effective of the fatty amines. In time-kill curves, lauric acid and myristylamine produced a bactericidal effect and a bacteriostatic effect at 4-fold the MIC, respectively. The antimicrobial activities of lauric acid and myristylamine were decreased by human plasma. Cytotoxicity of 3 saturated fatty acids and 3 fatty amines was examined in cultured endothelial cells. Although cytotoxicity of fatty amines was severer than that of saturated fatty acids, myristylamine showed the highest value of apparent therapeutic index among them. DOX-96 was useful for screening antimicrobial substances, especially in the case of insoluble substances. We found that myristylamine showed anti-MRSA activity comparable to that of vancomycin and teicoplanin.
- 著者
- HIROKO YOSHIDA KHOSHI NORIKOSHI TAKASHI KITAHARA KOICHIRO YOSHIHARA
- 出版者
- THE JAPANESE SOCIETY FOR ANIMAL PSYCHOLOGY
- 雑誌
- 動物心理学研究 (ISSN:09168419)
- 巻号頁・発行日
- vol.41, no.2, pp.88-99, 1992-03-25 (Released:2010-11-18)
- 参考文献数
- 31
- 被引用文献数
- 1
Four chimpanzee mother-infant pairs belonging to Tama Zoological Park were observed in order to see how this relationship develops. The main study run from August 1986 to December 1989. Each mother-infant pair was observed for 30 minutes once a week. All behavior patterns were recorded and analyzed.The data showed that the process of the chimpanzee infant's development of attachment resembled closely that of humans from the pre-attachment-phase to a goal-corrected-partnership (Bowlby's model 1969). Moreover, three or four-year-old chimpanzee infants seemed to have some conflict with their mother, because ambivalent behavior occurred at that time. Infants whimpered for their mother without cause for fear and soon after the mother held them, they left her and whimpered again. Such ambivalent behavior patterns towards the mother are often observed in human infants.