- 著者
-
Akira Matsumoto
Mai Yuasa
Hiroko Matsumoto
Mai Sanjo
Miyuki Tabata
Tatsuro Goda
Toru Hoshi
Takao Aoyagi
Yuji Miyahara
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- vol.45, no.4, pp.460-462, 2016-04-05 (Released:2016-04-05)
- 参考文献数
- 30
- 被引用文献数
-
11
In an attempt to develop a totally synthetic, self-regulated insulin delivery system to treat diabetes, N-substituted poly(acrylamide) copolymer gels bearing boronate functionality have been chemically optimized so as to undergo an abrupt and glucose-dependent change in hydration. This study highlights an importance of fine-tuning the mesh size of the gel relative to that of insulin in order to achieve the better controlled-release in a manner less sensitive to the temperature, even with an apparently marginal change of hydration.