著者

Kazuko Iwamoto Hirokazu Kawamoto Fumiaki Takeshita Shinichi Matsumura Ikuto Ayaki Tatsuya Moriyama Nobuhiro Zaima

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

pp.ess19135, (Released:2019-08-14)

被引用文献数

10

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Ginkgo biloba extract (GBE) is widely used as herbal medicine. Preventive effect of GBE against dementia, including Alzheimer’s disease, has been reported. The bioactive compounds in GBE that impart these beneficial effects, flavonoids and terpene lactones, have poor bioavailability. Our previous study found distribution of bioactive compounds of sesame extract in mice brain after mixing it with turmeric oil. Here, we evaluate the distribution of bioactive compounds of GBE by combining it with the mixture of sesame extract and turmeric oil (MST). The content of terpene lactones in mice serum was significantly increased in a dose-dependent manner after administration of GBE. However, the contents of terpene lactones in mice brain were not significantly changed. Concentration of ginkgolide A in mice brain increased significantly when GBE was co-administrated with MST than when GBE was administered alone. These results suggest that MST may be effective in enhancing the bioavailability of ginkgolide A in GBE.

著者

Mayo HIGASHIHARA Rena FUJISHIMA Hirona KUGO Tatsuya MORIYAMA Nobuhiro ZAIMA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.Supplement, pp.S143-S145, 2022-11-30 (Released:2022-11-25)

参考文献数

19

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Dietary habit is closely associated with healthspan. Functional food factors are key to maintaining a health metabolism in our bodies. Because functional food factors are main components to determine the quality of foods, many technologies have been established to analyze functional factors in foods. High-performance liquid chromatography-mass spectrometry or gas chromatography-mass spectrometry is a solid approach to detect functional food factors with high sensitivity and specificity. Findings obtained from these mass spectrometric approaches play essential roles in estimating the quality of foods. However, these technologies are not available for the analysis of the spatial distribution of molecules of interest in foods. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is considered an ideal approach to visualize distribution of molecules in foods. MALDI-MSI is a two-dimensional MALDI-MS technology that can detect compounds in a tissue section without purification, separation, or labeling. MALDI-MSI can be used to visualize the spatial distribution of wide range of food components including protein, peptides, amino acids, lipids, carbohydrate, and vitamins. Although the methodology of MALDI-MSI in food science is not yet fully established, the versatility of MALDI-MSI is expected to open a new frontier in food science. In this mini review, we briefly summarized the applications of MALDI-MSI in the field of food science.

著者

Teruyoshi Tanaka Hanjun Tang Kazuya Umehara Tatsuya Moriyama Yukio Kawamura

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

pp.FSTR-D-22-00103, (Released:2022-11-11)

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As the average longevity of humans increases, the number of patients with osteoporosis has also increased. Chemoprevention for osteoporosis, especially through food intake, may extend the healthy life expectancy. We previously reported that kudzu (Pueraria lobata) vine ethanol extract (PVEE) in the diet (20 mg/kg body weight/day) suppresses bone resorption and prevents bone loss in ovariectomized mice. However, experiments with lower PVEE concentrations are necessary to determine whether PVEE is a suitable functional food resource to improve osteoporosis. This study thus examined the effects of PVEE intake (2 or 5 mg/kg body weight/day, approximately 0.07 or 0.17 mg PVEE isoflavone/day/mouse) for 6 months. The dose was calculated on the basis of the recommended daily isoflavone allowance in Japan. Both 5 and 2 mg PVEE successfully prevented ovariectomy-induced bone loss in mice. These results indicated that PVEE was effective at these doses. Thus, PVEE has the potential to be a promising resource for osteoporosis-preventing functional foods.