著者

Yosuke OKAZAKI Tatsuya SASAKI Kouji KAWAI Kakeru HOSOMOTO Susumu SASADA Takao YASUHARA Tomoyuki AKIYAMA Yoshiyuki HANAOKA Isao DATE

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.307-312, 2022-12-31 (Released:2022-09-15)

参考文献数

23

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Early-onset isolated (DYT1) dystonia is one of the most common forms of primary dystonia in childhood, and deep brain stimulation of the globus pallidus internus (GPi-DBS) is a highly effective treatment for it. However, the effectiveness of GPi-DBS in monozygotic twins with DYT1 dystonia has never been reported globally. Here, we report the cases of monozygotic twins with DYT1 dystonia who were treated using GPi-DBS, and we include a literature review. The younger brother showed an abnormal gait, with external rotation of the right lower leg at 6 years old. The symptoms gradually became so severe that he had difficulty walking on his own at 9 years of age. Treatment with levodopa-carbidopa partially resolved his symptoms, but most of the symptoms remained. Meanwhile, the older brother developed dystonia in both upper limbs at 8 years of age, with gradual symptom progression. At 13 years of age, they were diagnosed with DYT1 dystonia. Bilateral GPi-DBS was performed in both patients at 16 years of age. Their symptoms remarkably improved after surgery. The Burke-Fahn-Marsden dystonia rating scale (BFMDRS) movement score was reduced from 52 to 2 points for the younger brother and from 35 to 1 point for the older brother. Even if monozygotic twins have the same genes, the onset and severity of symptoms might vary in accordance with differences in epigenomic profiles. However, GPi-DBS treatment was very effective for the two cases; thus, we should consider the surgical interventions for each patient.

著者

内田 智士 佐々木 達矢 Uchida Tatsuya Sasaki Satoshi

雑誌

【C】平成28年電気学会電子・情報・システム部門大会講演論文集

巻号頁・発行日

2016-08-31

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本発表は,集団がある課題を解決していく上で,個々の学習過程の違いが結果にどのような影響をもたらすかについて,数理的なモデルにより調べることを目的とする。学習過程としては,従来の個人主義的学習方法と,アクティブ・ラーニングに代表される構成主義的な学習方法(分人主義的学習方法)とを比較検討する。また集団が解決すべき課題としては,協調性の発展(協調関係の形成)を取り上げる。協調性は,幼児教育に関する種々の研究によって,最近特にその重要性が明らかになりつつある非認知的スキルのひとつだからである。個人主義的学習においては集団が一様になる傾向があるのに対して,構成主義的学習においては,集団に多様性がもたらされることが明らかとなる。

著者

Tatsuya SASAKI Kensuke MURAKAMI Atsushi SAITO Shinya HARYU Masayuki KAMEYAMA Yoshiharu TAKAHASHI Satoru TAKAMURO Nana KATO Toshiki ENDO

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2023-0007, (Released:2023-06-28)

参考文献数

24

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The usefulness of transcranial motor evoked potentials (Tc-MEPs) in clipping surgery has been reported. However, numerous false positive and false negative cases were reported. We report the usefulness of a new protocol compared with direct cortical MEP (Dc-MEP).Materials were 351 patients who underwent aneurysmal clipping under simultaneous monitoring of Tc- and Dc-MEPs. A total of 337 patients without hemiparesis and 14 with hemiparesis were separately analyzed. Intraoperative changes of Tc-MEP thresholds were examined in the first 50 patients without hemiparesis. The stimulation strength of Tc-MEP was set at +20% of the stimulation threshold. As thresholds changed intraoperatively, thresholds were examined every 10 min and changed stimulation strength.Stimulation thresholds of Tc-MEP were significantly decreased after craniotomy and significantly increased after CSF aspiration. The recording ratios of Tc- and Dc-MEPs were 98.8% and 90.5%, respectively. Out of 304 patients without MEP change, 5 patients developed transient or mild hemiparesis with infarction of the territory of the perforating artery arising from the posterior communicating artery. Out of 31 patients whose MEP transiently disappeared, 3 patients developed transient or mild hemiparesis. The other two patients without MEP recovery manifested persistent hemiparesis. In 14 patients with preoperative hemiparesis, 3 patients whose healthy/affected ratio of Tc-MEP was large developed severe persistent hemiparesis.We clarified the intraoperative changes of Tc-MEP thresholds for the first time. A new protocol of Tc-MEP that followed thresholds and changed stimulation strength to +20% of thresholds is useful for stable monitoring. The usefulness of Tc-MEP is the same as that or better than that of Dc-MEP.

著者

Takeshi HIGUCHI Haruna OIZUMI Tatsuya SASAKI Tadahiro AITA

出版者

The Ceramic Society of Japan

雑誌

Journal of the Ceramic Society of Japan (ISSN:18820743)

巻号頁・発行日

vol.117, no.1368, pp.873-877, 2009 (Released:2009-08-01)

参考文献数

25

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A silica-polymer composite with oriented macropores was fabricated from tetraethoxysilane (TEOS) incorporated with poly(ethylene glycol) (PEG) via a sol-gel method. The solution mixture containing PEG and TEOS after hydrolysis was subjected to shear stress so that the macroporous structure generated by spinodal decomposition during the process of polycondensation to a silica-PEG-rich phase and a solvent-rich phase was elongated and oriented toward the shear flow direction. It was found that shear flow is effective for macropore elongation after the solution mixture becomes turbid. The optimum PEG content for macropore elongation was also revealed. The elongation ratio of the macropores was dependent to a certain extent on the shear rate.