- 著者
- Satoshi TAKEMOTO Akane YAMAMOTO Shozo TOMONAGA Masayuki FUNABA Tohru MATSUI
- 出版者
- Center for Academic Publications Japan
- 雑誌
- Journal of Nutritional Science and Vitaminology (ISSN:03014800)
- 巻号頁・発行日
- vol.59, no.6, pp.560-563, 2013 (Released:2014-01-30)
- 参考文献数
- 19
- 被引用文献数
- 7 18
Mast cells, multifunctional effector cells of the immune system, are implicated in the pathogenesis of hepatic steatosis and fibrosis. Magnesium (Mg) deficiency was reported to increase triglyceride concentration in the liver, and to exacerbate the collagen deposition induced by carbon tetrachloride in the liver. Although Mg deficiency increases mast cells in the small intestine, the kidney and bone marrow, the effect of Mg deficiency on mast cells has not been clarified in the liver. We examined the emergence of mast cells in the liver of Sprague-Dawley rats given an Mg-deficient diet. Rats were fed a control diet or an Mg-deficient diet for 4 wk. Mg deficiency increased the levels of mRNA known to be expressed by mast cells in the liver; the mRNA of α- and β-chain high-affinity immunoglobulin E receptor (FcεR1α, FcεR1β), and the mRNA of mast cell protease 1 (Mcpt1), and mast cell protease 2 (Mcpt2). Histological observation showed that some mast cells were locally distributed around portal triads in the Mg-deficient group but mast cells were scarcely found in the control group. These results clearly indicate that Mg deficiency induces the emergence of mast cells around portal triads of the liver in Sprague-Dawley rats.
- 著者
- Akira MATSUI Tomoko OSAWA Hirofumi FUJIKAWA Yo ASAI Tohru MATSUI Hideo YANO
- 出版者
- Japanese Society of Equine Science
- 雑誌
- Journal of Equine Science (ISSN:13403516)
- 巻号頁・発行日
- vol.13, no.4, pp.109-112, 2002 (Released:2003-04-10)
- 参考文献数
- 13
We examined total sweating rate (SR) and the amount of mineral (Na, K, Ca, Mg, Fe, P, Zn and Cu) loss through sweat in 2-year-old horses during exercise for approximately 2,000 m at a speed of 700 m/min, at cool ambient temperature. The total SR was estimated by the unit area SR on the neck by filter paper within a capsule. Mean total SR was 1.55 ± 0.47 (SD) kg. The ratio of sodium loss to the requirements reported by National Research Council reached 23% and that of potassium was 7%. The ratio of other mineral losses to the requirements reported by National Research Council was 2% or less. These results suggested that sodium had to be supplemented to the horse, but there was no need to add extra minerals to the diet to compensate for mineral losses of calcium, magnesium, iron, phosphorus, zinc and copper through sweat during exercise with light intensity and at a cool ambient temperature.