- 著者
- Masato Otsuka Tomoharu Mine Kentarou Ohuchi Shinji Ohmori
- 出版者
- The Japanese Biochemical Society
- 雑誌
- The Journal of Biochemistry (ISSN:0021924X)
- 巻号頁・発行日
- vol.119, no.2, pp.246-251, 1996 (Released:2008-11-18)
- 参考文献数
- 19
The metabolism of diacetyl (2, 3-butanedione), acetoin (3-hydroxy-2-butanone), and 2, 3-butanediol, which are metabolites of acetaldehyde was quantitatively investigated using rat liver homogenate, liver perfusion, and in vivo experiments. Diacetyl and acetoin were reduced to 2, 3-butanediol in these experiments, but acetoin and 2, 3-butanediol were scarcely oxidized to diacetyl, indicating that the reduction reaction to 2, 3-butanediol from diacetyl occurs actively in rat liver. The formation of acetoin from diacetyl required either NADH or NADPH as a reductant, while the reduction of acetoin to 2, 3-butanediol required NADH. Acetoin and 2, 3-butanediol were more readily accumulated than diacetyl in brain tissue.