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1 0 0 0 OA Applicability of 3-Dimensional Quantitative Coronary Angiography-Derived Computed Fractional Flow Reserve for Intermediate Coronary Stenosis

著者
Kyoichiro Yazaki Masato Otsuka Shohei Kataoka Mitsuru Kahata Asako Kumagai Koji Inoue Hiroshi Koganei Kenji Enta Yasuhiro Ishii
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-16-1261, (Released:2017-03-22)
参考文献数
17
被引用文献数
41
Background:Quantitative flow ratio (QFR) is a newly developed image-based index for estimating fractional flow reserve (FFR).Methods and Results:We analyzed 151 coronary arteries with intermediate stenosis in 142 patients undergoing wire-based FFR measurement using dedicated software. Predefined contrast flow QFR, which was derived from 3-dimensional quantitative coronary angiography (3-D QCA) withThrombolysis in Myocardial Infarction (TIMI) frame counts, was compared with FFR as a reference. QFR had good correlation (r=0.80, P<0.0001) and agreement (mean difference: 0.01±0.05) with FFR. After applying the FFR cut-off ≤0.8, the overall accuracy rate of QFR ≤0.8 was 88.0%. On receiver operating characteristics analysis, the area under the curve was 0.93 for QFR. In contrast, 3-D QCA-derived anatomical indices had insufficient correlation with FFR and diagnostic performance compared with QFR.Conclusions:QFR had good correlation and agreement with FFR and high diagnostic performance in the evaluation of intermediate coronary stenosis, suggesting that QFR may be an alternative tool for estimating myocardial ischemia.

1 0 0 0 OA A Detoxication Route for Acetaldehyde: Metabolism of Diacetyl, Acetoin, and 2, 3-Butanediol in Liver Homogenate and Perfused Liver of Rats

著者
Masato Otsuka Tomoharu Mine Kentarou Ohuchi Shinji Ohmori
出版者
The Japanese Biochemical Society
雑誌
The Journal of Biochemistry (ISSN:0021924X)
巻号頁・発行日
vol.119, no.2, pp.246-251, 1996 (Released:2008-11-18)
参考文献数
19
The metabolism of diacetyl (2, 3-butanedione), acetoin (3-hydroxy-2-butanone), and 2, 3-butanediol, which are metabolites of acetaldehyde was quantitatively investigated using rat liver homogenate, liver perfusion, and in vivo experiments. Diacetyl and acetoin were reduced to 2, 3-butanediol in these experiments, but acetoin and 2, 3-butanediol were scarcely oxidized to diacetyl, indicating that the reduction reaction to 2, 3-butanediol from diacetyl occurs actively in rat liver. The formation of acetoin from diacetyl required either NADH or NADPH as a reductant, while the reduction of acetoin to 2, 3-butanediol required NADH. Acetoin and 2, 3-butanediol were more readily accumulated than diacetyl in brain tissue.