- 著者
-
Toshiaki Murai
Yuichiro Mutoh
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- vol.41, no.1, pp.2-8, 2012-01-05 (Released:2011-12-24)
- 参考文献数
- 99
- 被引用文献数
-
67
Sequential reactions of thioamides and thioformamides with organolithium and Grignard reagents are described. Thioiminium salts derived from these sulfur isologues of amides readily react with lithium acetylides to lead to several types of products, including α,β-unsaturated ketones, whereas sequential additions of lithium acetylides and Grignard reagents afford propargylamines. The direct addition of organolithium and Grignard reagents to thioformamides proceeds with high efficiency to give a range of tertiary amines.