著者

Masanori Iwata Toyozo Takahashi Yuri Takahashi Akihiko Ito Yoshiharu Machida

出版者

Japanese Society of Pharmaceutical Health Care and Sciences

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.1, pp.63-68, 2001-02-10 (Released:2011-03-04)

参考文献数

16

被引用文献数

3 4

---

The therapy of mass alimentary intoxication caused by Salmonella and Enteropathogenic Escherichia coli is discussed. Endotoxin causes fervescence, disseminated intravascular coagulation or shock. When antibiotics are administered for the treatment of alimentary intoxication, toxicity of the endotoxin from the defluvium of bacillus mort body can cause serious symptoms.We noted the strong adsorption force of medicinal carbon and evaluated the endotoxin adsorption ability of medicinal carbon quantitatively using a chromogenic endotoxin specific assay quantitatively. Methods for evaluating damage due to the oral invasion of endotoxin have hardly been developed. The presence of alimentary intoxication due to a large quantity of endotoxin in intestine was assumed, and an in vivo test was performed to evaluate the endotoxin adsorption ability of medicinal carbon based on the influence of particle size. An in vitro test showed the adsorption coefficient to increase with the reaction times of medicinal carbon and endotoxin. The quantity of adsorption of endotoxin decreased as the particle size of medicinal carbon increased. As in vivo test showed that a change in the body temperature of mouse, which is an index of the physiological activity of endotoxin, was reduced by the oral administration of medicinal carbon. Consisting of small sized particles is thus considered to have a useful synergistic effect on the antibiotic treatment of food poisoning.