- 著者
-
Katsuhiro YAMASAKI
Masami NAKANO
Takuya KAWAHATA
Haruyo MORI
Toru OTAKE
Noboru UEDA
Isao OISHI
Rie INAMI
Megumi YAMANE
Miki NAKAMURA
Hiroko MURATA
Tsutomu NAKANISHI
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.21, no.8, pp.829-833, 1998-08-15 (Released:2008-04-10)
- 参考文献数
- 14
- 被引用文献数
-
75
158
The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha×piperita "grapefruit mint", Mentha×piperita var. crispa, Ocimum basilicum cv "cinnamon", Perilla frutescens var. crispa f.viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16μg/ml). The active components in the extract samples were found to be water-solubel polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cels with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.