- 著者
- Jun IWAMOTO Tsuyoshi TAKEDA Yoshihiro SATO Chwan-Li SHEN James K. YEH
- 出版者
- Japanese Association for Laboratory Animal Science
- 雑誌
- Experimental Animals (ISSN:13411357)
- 巻号頁・発行日
- vol.67, no.3, pp.R3, 2018 (Released:2018-07-30)
- 被引用文献数
- 1
The following articles have been retracted by the Editorial Board of Experimental Animals, because some parts of their contents were published elsewhere.
- 著者
- Jun Iwamoto Tsuyoshi Takeda Yoshihiro Sato
- 出版者
- The Keio Journal of Medicine
- 雑誌
- The Keio Journal of Medicine (ISSN:00229717)
- 巻号頁・発行日
- vol.54, no.2, pp.55-59, 2005 (Released:2006-06-20)
- 参考文献数
- 28
- 被引用文献数
- 30 75
This paper reviews the interventions to stabilize calcium balance and bone metabolism and prevent bone loss in astronauts during space flight. Weightlessness during space flight results in calcium, vitamin D, and vitamin K deficiency, increases urinary calcium excretion, decreases intestinal calcium absorption, and increases serum calcium level, with decreased levels of serum parathyroid hormone and calcitriol. Bone resorption is increased, whereas bone formation is decreased. The loss of bone mineral density (BMD) in the spine, femoral neck and trochanter, and pelvis is 1.0-1.6% per month. High calcium intake and vitamin D supplementation during space flight does not affect bone metabolism, but prevents an elevation of serum calcium level through increased calcitriol level, while vitamin K counteracts the reduction in bone formation. However, there are no data to show the efficacy of pharmaceutical agents for prevention of development of osteoporosis in astronauts during flight, although the preventative effect of bisphosphonates, testosterone, and vitamin K2 on cancellous bone loss in the tibia or BMD loss in the hindlimb was reported in tail-suspended mature rats. It still remains uncertain whether these agents can prevent cortical bone loss caused by weightlessness in tail-suspended rats. Therefore, in addition to calcium, vitamin D, and vitamin K supplementation, agents that have both potent anti-resorptive and anabolic effects on cancellous and cortical bone may be needed to stabilize calcium balance and bone metabolism and prevent bone loss in astronauts duringspace flight.
- 著者
- Jun IWAMOTO Tsuyoshi TAKEDA Yoshihiro SATO
- 出版者
- Japanese Association for Laboratory Animal Science
- 雑誌
- Experimental Animals (ISSN:13411357)
- 巻号頁・発行日
- vol.54, no.1, pp.1-6, 2005 (Released:2005-02-23)
- 参考文献数
- 31
- 被引用文献数
- 55 71
Increasing peak bone mass at skeletal maturity, minimizing bone loss during middle age and after menopause, and increasing bone mass and preventing falls in advanced age are important measures for preventing osteoporotic fractures in women. Exercise has generally been considered to have a positive influence on bone health. This paper reviews the effects of treadmill exercise on bone in young, adult, ovariectomized, and osteopenic female rats. Treadmill exercise increases cortical and cancellous bone mass of the tibia as a result of increased bone formation and decreased bone resorption in young and adult rats. The increase in lumbar bone mass seems to be more significant when long-term exercise is applied. Treadmill exercise prevents cancellous bone loss at the tibia as a result of suppressed bone resorption in ovariectomized rats, and increases bone mass of the tibia and mechanical strength of the femur, as a result of suppressed bone resorption and increased bone formation in osteopenic rats after ovariectomy. Treadmill exercise transiently decreases the serum calcium level as a result of accumulation of calcium in bone, resulting in an increase in serum 1,25-dihydroxyvitamin D3 level and a decrease in serum parathyroid hormone level. We conclude that treadmill exercise may be useful to increase bone mass in young and adult rats, prevent bone loss in ovariectomized rats, and increase bone mass and bone strength in osteopenic rats, especially in the long bones at weight-bearing sites. Treadmill exercise may have a positive effect on the skeleton in young, and adult, ovariectomized, and osteopenic female rats.
- 著者
- Jun IWAMOTO Azusa SEKI Tsuyoshi TAKEDA Yoshihiro SATO Harumoto YAMADA James K. YEH
- 出版者
- Japanese Association for Laboratory Animal Science
- 雑誌
- Experimental Animals (ISSN:13411357)
- 巻号頁・発行日
- vol.67, no.3, pp.R1, 2018 (Released:2018-07-30)
- 被引用文献数
- 1
The following articles have been retracted by the Editorial Board of Experimental Animals, because some parts of their contents were published elsewhere.
- 著者
- Jun IWAMOTO Azusa SEKI Tsuyoshi TAKEDA Yoshihiro SATO Harumoto YAMADA James K. YEH
- 出版者
- Japanese Association for Laboratory Animal Science
- 雑誌
- Experimental Animals (ISSN:13411357)
- 巻号頁・発行日
- vol.67, no.3, pp.R2, 2018 (Released:2018-07-30)
- 被引用文献数
- 1
The following articles have been retracted by the Editorial Board of Experimental Animals, because some parts of their contents were published elsewhere.
- 著者
- YOSHIHIRO SATO YOSHIAKI HONDA KAZUO UMENO NORIMASA HAYASHIDA JUN IWAMOTO TSUYOSHI TAKEDA HIDEO MATSUMOTO
- 出版者
- 久留米大学医学部
- 雑誌
- The Kurume Medical Journal (ISSN:00235679)
- 巻号頁・発行日
- vol.57, no.4, pp.117-124, 2010-10-30 (Released:2011-07-22)
- 参考文献数
- 36
- 被引用文献数
- 2 4
The editorial board announced this article has been retracted because of scientific misconduct. If you have any further question, please contact us at: kmjedit@kurume-u.ac.jp