著者

TOSHIMITSU SHINGU TAKAHIRO UCHIDA MASUJI NISHI KAZUO HAYASHIDA SEIZABURO KASHIWAGI JUN HAYASHI MASARO KAJI

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.29, no.3, pp.123-125, 1983-04-15 (Released:2010-02-08)

参考文献数

3

被引用文献数

9 16

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Seventeen hospital employees were inoculated with 40 -μcg hepatitis B vaccine as a part of a phase 1 trial in Japan. More than 90 per cent of the subjects developed antibodies against HBsAg after two doses of the vaccine. The third dose had a booster effect. Seven of the 16 vaccinated women experienced menstrual abnormalities after the first and/or second inoculation. These included hypomenorrhea, too short menstruation, oligomenorrhea and polymenorrhea. One subject also suffered from acne after the third inoculation. These abnormalities may be side effects of the hepatitis B vaccine which have not been reported previously.

著者

MUNETSUGU NISHIMURA TAKEHARU KOGA TOMOKO KAMIMURA RUMI SATO HIROKI NATORI KAZUHIKO MATSUO HISAMICHI AIZAWA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.58, no.1, pp.9-14, 2011-02-28 (Released:2011-10-26)

参考文献数

16

被引用文献数

3 5

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Patients with asthma are often complicated by allergic rhinitis, and the intimate pathophysiological association between allergic rhinitis and asthma often imposes a significant morbidity on affected individuals. The present study was conducted to assess the clinical efficacies of leukotriene receptor antagonists (LTRAs) and anti-histamines on asthma as an add-on therapy in patients with asthma complicated by allergic rhinitis. Consecutive patients with asthma were recruited to fill in systematic self-administered questionnaires concerning symptoms and conditions related to asthma and allergic rhinitis. The questionnaire was conducted twice, one month apart, and the attending physicians gave detailed information on disease control and medications on both occasions. In the study 3,140 patients with asthma participated, and 634 had concomitant allergic rhinitis (mean age: 53.1, 389 female). The second survey disclosed that treatment with LTRAs or anti-histamines had been added in 26 patients and 19 patients, respectively, without any changes in other medications. There were no significant differences in age, gender, severity of disease, or baseline treatments. The initial survey indicated that the patients who were treated with LTRAs had significantly more severe asthma-related symptoms (i.e. wheeze, cough and sleep disturbance) and experienced greater dissatisfaction with the treatment than did those who were treated with anti-histamines. The second survey disclosed significant reductions in sneezing (p=0.03), rhinorrhea (p=0.01), dyspnea (p=0.046), sleep disturbance (p=0.02), over-all asthma symptoms (p=0.013), and an improvement in satisfaction with treatment (p=0.019) in patients to whom LTRAs were added-on, whereas the patients receiving anti-histamines reported no significant changes in these symptoms. These results suggest that LTRAs are more effective than anti-histamines as an add-on therapy in symptomatic patients with asthma complicated by allergic rhinitis.

著者

GEORGE N ROMANOS ARETI V VOLIOTI PANAGIOTIS I HATZIMANOLIS CHRISTOS KOUTSERIMPAS GEORGE SAMONIS

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

pp.MS6723004, (Released:2022-09-16)

参考文献数

23

被引用文献数

2

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Summary: Bisphosphonate-related osteonecrosis of the jaws represents a well-recognized complication occurring in patients being administered drugs for the treatment of osteoporosis and/or malignant disease. Treatment of this condition, aiming to alleviate the symptoms and restore functional status, represents a challenge for the maxillofacial surgeon. Conservative management has been proposed for early stages of this condition, while surgical intervention is mandatory for advanced disease. Two cases of severe bisphosphonate-related osteonecrosis of the jaw that achieved complete osseous recontouring after partial mandibulectomy, are presented.

著者

PUHAN HE JENNIFER CAUGHEY R. SHANE TUBBS JOE IWANAGA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

pp.MS682016, (Released:2023-05-12)

参考文献数

18

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Summary: Background: The purpose of this study was to investigate the structure of the incisive canal using dry maxillae harvested from human cadavers. Methods: Seven dry maxillae were harvested from adult Caucasian human cadavers. The incisive canals in all specimens were observed from an intraoral viewpoint with the naked eye and under a surgical microscope with 20× magnification. Results: All specimens had a single incisive foramen leading to different numbers of canals. Two specimens had a single canal (Type I), two were double (Type II), and three had triple canals (Type III). In both type I specimens, the canal was centered in the incisive foramen. Type II had a septum between the two canals. This septum was irregular in shape near the entrance of the canal but smooth inside the canal. The canals were positioned asymmetrically within the foramen. Type III had two septa between the three canals. Again, those located near the entrance of the canal were irregular while those inside the canal were smooth. The orientation of the lumina differed from one another in the type III canals. Conclusion: The study identified morphological variations in the anatomy of the incisive canal, underscoring the importance of pre-surgical planning in the administration of local anesthesia, placement of dental implants, or removal of impacted teeth in the anterior maxillary region.

著者

YUYA TSUKADA HIROO MATSUSE NATSUKO SHINOZAKI YOSHIO TAKANO TAKESHI NAGO NAOTO SHIBA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.65, no.4, pp.145-154, 2018-12-31 (Released:2020-01-23)

参考文献数

23

被引用文献数

4

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Summary: Background: Osteoarthritis of the knee (KOA) is the most common cause of disability in both the United States and in Japan. The Hybrid training system (HTS) has been developed as a resistance exercise method combining electrical stimulation with voluntary exercise. The purpose of the present study is to compare the effects of a conventional rehabilitation program with or without HTS on knee muscle strength and physical function after Total knee arthroplasty (TKA). Methods: We conducted a 12-week randomized controlled trial, using standard rehabilitation (the control group, n = 27) or standard rehabilitation plus HTS (the HTS group, n= 26), in 53 female patients after TKA. The HTS group underwent HTS three times per week for twelve weeks after TKA. Muscle strength, thigh circumference, physical functional testing, QOL and knee pain were assessed before surgery, 6 and 12 weeks after TKA. Results: There was a significant decrease in quadriceps strength and thigh circumference on the operative side in the control group, but not in the HTS group at 6 weeks. Hamstring strength on the operative side in the HTS group significantly increased and thigh circumference was bigger than in the control group at 12 weeks. Physical function improved at 6 weeks in the HTS group, but not in the control group. Knee pain significantly improved in both groups at 6 weeks. Conclusions: HTS was effective in preventing quadriceps weakness and in improving physical function and QOL after TKA.

著者

JOE IWANAGA FRANCISCO REINA BASEM ISHAK MIGUEL ANGEL REINA AARON S. DUMONT R. SHANE TUBBS

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.68, no.2, pp.75-80, 2021-06-30 (Released:2023-07-03)

参考文献数

17

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Summary: Background: Our goal was to revisit the innervation of the adductor muscles of the thigh and add new evidence to currently existing knowledge. Methods: Ten thighs from five fresh frozen cadavers were dissected. Obturator nerve innervation to the pectineus, obturator externus, adductor brevis, adductor magnus, adductor longus, and gracilis was documented. Results: The adductor longus and gracilis were innervated by the anterior branch in 100%, and the adductor magnus was innervated by the posterior branch in 100%. The adductor brevis was supplied by both the anterior and posterior branches in 90%. The obturator externus was innervated by the posterior branch in 60% and a direct branch from the main trunk in 10%. No innervation of the obturator externus by the obturator nerve was found in 30%. Conclusions: The obturator externus and adductor brevis need to be explored further to clarify their innervation.

著者

SHOGO KIKUTA JOE IWANAGA BASEM ISHAK AARON S. DUMONT R. SHANE TUBBS

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.67, no.1, pp.1-4, 2020-03-31 (Released:2022-03-11)

参考文献数

23

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Summary: This paper aimed to better describe the anatomy of the superficial anterior atlanto-occipital ligament of the craniocervical junction and discuss this ligament’s potential function and clinical implications. A broad literature review on the anatomical features and findings of the superficial anterior atlanto-occipital ligament was performed. The superficial anterior atlanto-occipital ligament is located anterior to the anterior atlanto-occipital membrane. However, the physiological role of the superficial anterior atlanto-occipital ligament is still unclear due to a lack of anatomical and biomechanical studies although one study has suggested that this ligament is a secondary stabilizer of the craniocervical junction. Further studies are needed to clarify the function and anatomy of the superficial anterior atlanto-occipital ligament.

著者

AKIO HORI TATSUO AKIMOTO

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.20, no.1, pp.57-66, 1973-06-15 (Released:2009-08-11)

参考文献数

8

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Two cases of male fetishism were interviewed and the process of appearance of perversion and its development were disclosed. The object of fetishism is women's panties in the first example and women's rubber swimming cap in the second example. The generation mechanism of fetishism in both cases seems to be rooted in the background of homosexualism. Though they are both rooted in homosexualism, the first case seems to be causedby the castration anxiety toward authoritative father. While in the second case, the homosexual tendency seems to be derived from the narcissism in the boyhood of a beautiful boy as well as the sensual caress of a cousin. The two cases were not given medical treatment for a special reason.

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.63, no.1.2, pp.49-49, 2016-07-31 (Released:2017-04-13)

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The editorial board announced this article has been retracted because of scientific misconduct. If you have any further question, please contact us at: kmjedit@kurume-u.ac.jp Article Title: The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a randomized controlled trial Authors: Yoshihiro Sato, Yoshiaki Honda, Kazuo Umeno, Norimasa Hayashida, Jun Iwamoto, Tsuyoshi Takeda and Hideo Matsumoto Journal Title: Kurume Medical Journal Volume: Vol. 57, 2011 Pages: 117-124

著者

SHIGEAKI AOYAGI SATORU TOBINAGA KUMIKO WADA SHIN-ICHI NATA HIROSHI YASUNAGA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

pp.MS681002, (Released:2023-02-08)

参考文献数

9

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Summary: Myocardial contusion is the most common cardiac injury from blunt chest trauma (BCT), whereas isolated valve injury is uncommon. We report a case of acute mitral regurgitation (MR) due to isolated valve injury after BCT. A 60-year-old man received an impact on his left chest by a car wheel three weeks prior to visiting our hospital. At the time a diagnosis of contusion of the chest wall without rib and sternal fractures was made. Thereafter, the patient had progressive worsening of heart failure symptoms. Eventually he developed dyspnea on slight exertion but echocardiographic evaluation was not performed at the time of diagnosis or during the three weeks prior to admission. At admission a holosystolic murmur was heard. Transthoracic echocardiography revealed prolapse of the posterior mitral leaflet due to torn chordae tendineae with severe MR and normal left ventricular wall motion. At surgery, torn chordae tendineae and a leaflet tear of the posterior leaflet were detected, and mitral valve repair was achieved without residual MR. Pathological examination of the torn chordae showed no findings of endocarditis or myxomatous degeneration. Echocardiography may play an important role for accurate and prompt diagnosis of cardiac lesions in patients with recent or a history of high-energy BCT.

著者

SHIGEAKI AOYAGI SATORU TOBINAGA KUMIKO WADA SHIN-ICHI NATA HIROSHI YASUNAGA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.67, no.2.3, pp.131-135, 2020-09-30 (Released:2022-11-16)

参考文献数

8

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Summary: Anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva is known as a cause of sudden cardiac death. However, it is often asymptomatic and incidentally diagnosed during evaluation for other cardiac diseases. We report a case of anomalous aortic origin of the right coronary artery (RCA) from the left sinus of Valsalva (ARCA) detected incidentally in a patient with degenerative mitral regurgitation (MR). A 47-year-old man, who had no history of myocardial ischemic symptoms on exertion, was admitted for sudden orthopnea. ECG revealed no ischemic changes and arrhythmias. Echocardiography demonstrated MR due to torn chordae of the posterior mitral leaflet. Computed tomography (CT) revealed the RCA arising from the left sinus of Valsalva at an acute angle and taking an interarterial course between the great arteries. The proximal RCA showed a circular shaped cross-section on CT, suggesting no presence of an intramural segment. Considering refractory heart failure and no history of myocardial ischemic symptoms on exertion as well as the findings of the CT angiography, urgent mitral valve repair was undertaken without surgical intervention for the anomalous RCA, and without evaluating myocardial ischemia. The patient recovered uneventfully. Postoperatively, myocardial perfusion scintigraphy demonstrated no exercise-induced myocardial ischemia. Patients with ARCA who are asymptomatic and whose coronary course is not intramural can be managed without surgical intervention for an anomalous coronary artery.

著者

HARUNA MIDORI KUMAMOTO KENICHIRO YAITA

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.66, no.4, pp.247-251, 2019-12-31 (Released:2021-12-15)

参考文献数

21

被引用文献数

1

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Summary: Nosocomial infective endocarditis is a relatively rare, but critical disease. A Japanese man in his 80s with psoriatic arthritis that was being treated with prednisolone was admitted for dyspnea. The first diagnosis was healthcare-associated pneumonia, and piperacillin/tazobactam was started. The patient’s blood culture was negative at the time of admission. During the treatment, acute kidney injury occurred due to the use of antibiotics. Hemodialysis was performed via a central venous catheter in the internal jugular vein. After treatment of pneumonia, the patient experienced a sudden onset of fever accompanied by a loss of consciousness. Blood cultures from the peripheral vein and the central venous catheter were positive for methicillin-susceptible Staphylococcus aureus. A transthoracic echocardiography revealed stringy strands of vegetation attached to the native mitral valve. Magnetic resonance imagings also showed a shower of emboli to the brain. Ceftriaxone and vancomycin were administered; however, the patient died following a massive cerebral infarction. Instances of in-hospital mortality from nosocomial endocarditis are higher than the rates of community-acquired endocarditis. Clinicians should pay close attention to risk factors for nosocomial infective endocarditis. These risk factors include long-term indwelling vascular devices, psoriatic arthritis and corticosteroid therapy.

著者

ARITOMO AO OSAMU TOKUNAGA CHIE AITA TOMOYA SAMURA YUJI SASAKI REIKO MIYASHITA TAKESHI MIYANOMAE

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.65, no.3, pp.91-97, 2018-09-30 (Released:2019-09-25)

参考文献数

19

被引用文献数

1 1

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Summary: Children with severe motor and intellectual disabilities (SMID) are continually exposed to stress due to their need to receive daily care. In particular, chronic physical and acute mental stress derived from daily medical care due to unstable health status are issues specific to SMID children. Therefore, it is important to approach these issues for the maintenance of their lives and quality of life. Seventeen children with a SMIDmedical care dependent group (SMID-MCDG) score of 25 or more will be enrolled in this study. Intervention by a hug while singing and rocking will be performed once a week for 24 weeks. The practitioner will sing, and slowly rock the child back and forth. Primary endpoint is high-frequency component of heart rate variability by frequency analysis. Secondary endpoints are low-frequency/high-frequency components of heart rate variability by frequency analysis, activity of salivary amylase, the incidence of adverse events, and changes in appearance. Frequency analysis of heart beat changes and salivary amylase activity are used as physiological indexes for assessing response to being held while singing and rocking. In this study, we will examine the efficacy and safety of hugging while singing and rocking as a practice of Ryouiku to promote relaxation in SMID-MCDG children.

著者

HIDETOMO HIMURO

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

pp.MS644002, (Released:2018-05-21)

参考文献数

32

被引用文献数

5

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Summary: Due to its strong oxidation activity, ozone has been well known to kill bacteria and exert toxic effects on human tissues. At the same time, ozone is being used for the treatment of diseases such as inflammatory bowel disease in some European countries. However, the use of ozone for therapeutic purposes, despite its strong toxic effects, remains largely unexplored. Interestingly, we found that intrarectal administration of ozone gas induced transient colonic epithelial cell damage characterized by the impairment of cell survival pathways involved in DNA replication, cell cycle, and mismatch repair. However, the damaged cells were rapidly extruded from the epithelial layer, and appeared to immediately stimulate turnover of the epithelial layer in the colon. Therefore, it is possible that ozone gas is able to trigger damage-induced rapid regeneration of intestinal epithelial cells, and that this explains why ozone does not cause harmful or persistent damage in the colon.

著者

DEREK R. SMITH PETER A. LEGGAT

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.52, no.3, pp.111-116, 2005 (Released:2006-08-04)

参考文献数

28

被引用文献数

2 6

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Over ten years after his death, the Sabin oral vaccine continues its profound influence on public health throughout the world. The annual incidence of polio has fallen dramatically since its introduction, with more than 300,000 lives being spared each year and an annual global saving in excess of 1 billion US dollars. In many ways, the development of an effective oral vaccine and its subsequent regulation by the World Health Organization can serve as a model for medical researchers. Our review describes the contribution of Albert Sabin as a medical researcher, and how his vaccine had a profound impact on the global reduction of polio infections. As many different factors influenced health-care last century, we describe Sabin's involvement with respect to prevailing scientific paradigms and public health issues of the time. Our paper also outlines the basic epidemiology of poliovirus and the historical development of an effective vaccine, both with and without Albert Sabin.

著者

YOSHIHIRO SATO YOSHIAKI HONDA KAZUO UMENO NORIMASA HAYASHIDA JUN IWAMOTO TSUYOSHI TAKEDA HIDEO MATSUMOTO

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.57, no.4, pp.117-124, 2010-10-30 (Released:2011-07-22)

参考文献数

36

被引用文献数

2 4

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The editorial board announced this article has been retracted because of scientific misconduct. If you have any further question, please contact us at: kmjedit@kurume-u.ac.jp

著者

SHIGETAKA ANEGAWA MINORU SHIGEMORI NOBUTO KOJO SHINKEN KURAMOTO

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.33, no.4, pp.181-186, 1987-03-31 (Released:2010-02-08)

参考文献数

30

被引用文献数

2

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Two cases of tension pneumocephalus produced by iatrogenic causes are described. Dural tears were produced by a pin of a Mayfield head-holder in one case and by pansinectomy in the other case. In addition, both cases had procedures which induce low cerebrospinal fluid (CSF), such as a ventriculo-peritoneal shunt or lumbar punctures. For production of tension pneumocephalus in these cases, CSF diversionary procedures may play an important role in the accumulation of air in the intracranial space.

著者

TERUO SASATOMI YOSHIAKI TSUJI TOSHIAKI TANAKA HIROYUKI HORIUCHI SHIN HYODO KIYOAKI TAKEUCHI OSAMU NAKASHIMA KAZUO SHIROUZU

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.47, no.2, pp.165-168, 2000-06-15 (Released:2009-08-11)

参考文献数

21

被引用文献数

5 9

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Schwann cell tumor occurring in the intestines is rare . A 68-year-old female came to our hospital because of hematemesis. Barium enema and colonoscopic examination revealed submucosal tumor in the sigmoid colon. Laboratory data showed mild anemia . No other abnormal finding was found in the blood chemistry. Tumor marker levels of carcinoembryonic antigen (CEA), CA19-9, alpha feto protein (AFP) and neuron specific enolase (NSE) were within normal limits. The exploratory laparotomy confirmed a large sigmoid colon tumor. She received sigmoid colectomy. The resected specimen was a submucosal tumor with central depression, measuring 4.7×3.5×3.0cm in size. The cut surface of the tumor was yellowish hue with necrosis. Histological examination showed spindle-shaped tumor cells with palisading comma-shaped nuclei and the nuclear pleomorphism. Immunohistochemical examination revealed that the tumor was positive for S-100 protein staining, and negative for Actin and for H.H.F. staining. These findings showed that this tumor was of Schwann cell origin. We report here the case in detail of a schwannoma in the sigmoid colon.

著者

HIDEKI KIDA SHIGEMI ANRAKU

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.26, no.1, pp.69-73, 1979-05-15 (Released:2009-08-11)

参考文献数

9

著者

YUSUKE ISHIDA YOSHINOBU OKABE HIDENORI TOKUYASU RYOHEI KAJI GEN SUGIYAMA TOMOYUKI USHIJIMA YU SASAKI MAKIKO YASUMOTO KEI KURAOKA OSAMU TSURUTA MICHIO SATA

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.60, no.2, pp.67-70, 2013-05-31 (Released:2014-04-14)

参考文献数

6

被引用文献数

3 10

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Ampullary tumors are diagnosed by endoscopic biopsy of the ampulla of Vater. We encountered a rare case of acute pancreatitis following endoscopic biopsy of the ampulla. A 53-year-old man referred to our hospital for detailed examination of a suspected tumor of the ampulla of Vater. We conducted endoscopic biopsy from the ampulla. He developed severe abdominal pain four hours after the procedure. The serum amylase and serum lipase were elevated and abdominal computed tomography (CT) revealed pancreatic enlargement and diffuse stranding of the peri-pancreatic fat, compatible with the findings of acute pancreatitis. We diagnosed the patient as having acute pancreatitis caused by endoscopic biopsy of the ampulla of Vater. Conservative therapy improved his condition, however, a large pancreatic walled-off necrosis (WON) developed. Therefore, we performed endoscopic ultrasonography (EUS)-guided cyst drainage on the 74th day after admission. The WON diminished gradually in size and the symptoms disappeared, and the patient was discharged in good physical condition on the 137th day after admission. In this case, the ampullary biopsy may have caused mucosal edema or intraductal hematoma, resulting in pancreatic duct obstruction. It is important for endoscopists both to be aware of this potential complication following endoscopic biopsy of the ampulla and to inform the patients about possible complications of this procedure.