- 著者
- Cong Li Xiang-lin Chi
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.44, pp.24-33, 2014-12-30 (Released:2017-06-01)
- 著者
- Xiang-Lin Chi Yong-Peng Yu Ke-Ping Bi
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.41, pp.17-36, 2013-09-30 (Released:2017-06-01)
The purpose of this study was to examine whether group intensive rehabilitation (GIR) can significantly improve lower limb functional outcome in patients early after stroke compared to routine rehabilitation (RR). Ninty-four patients were enrolled in this study who received GIR, individual intensive rehabilitation (IIR) or RR. Lower limb motor function was assessed using the Fugl-Meyer Assessment of Motor Recovery (FM). Dependence was recorded using the Modified Barthel Index (MBI), which is an index of daily living activities (ADL). Measures were taken before treatment and 3 weeks later respectively. Socioeconomics significance was assessed using rehabilitation cost-effectiveness ratio (CER). GIR and IIR produced greater gains than RR both in lower limb FM (p<0.01, p<0.01, respectively) and MBI (p=0.007, p=0.026, respectively) at 3 weeks after intervention. There were no significant differences both in FM and MBI score changes of lower limb between GIR and IIR (p=0.365, p=0.782, respectively). GIR had lower CER than IIR and RR (p<0.01, p<0.01, respectively). There were significant differences in CER between the three groups. Subjects in GIR had lower CER compared with those in IIR and RR (p<0.01, p<0.01, respectively). Patients receiving GIR or IIR could make greater gains than those receiving RR in lower limb motor function and ADL early after stroke, while there were no differences between those receiving GIR and IIR, which indicated that this beneficial effect was attributed to higher intensity of therapy, but had nothing to do with group factors. GIR may be a pragmatic, effective and economical method for patients early after stroke allowing for the optimal utilization of resources.
- 著者
- Zhao-qiang Zhang Xiao Sun Xiang-lin Chi Xian-chang Sun Hong Jiang
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.40, pp.54-65, 2013-03-30 (Released:2017-06-01)
- 参考文献数
- 11
Objective Modeling a stable and reproducible animal model of Parkinson's disease by rotenone intraperitoneal injection for further pathogenesis study of PD. Methods Twenty-seven male Wistar rats were used, which were randomly divided into three groups on average (Rotenone Injection, Vehicle Injection and Normal group). Rats of rotenone injection group (RIG) were administered rotenone (3.0 mg/kg/day) in a specialized vehicle through daily intraperitoneal injection; rats of vehicle injection group (VIG) were administered only special vehicle in the same way, rats of normal group (NG) didn't receive any injection. Checked the changes of its behavior and numbers of SNpc neurons to determine the model successful or not. Results Six rats of RIG developed part of Parkinson's symptoms at different time. All rats of RIG emerged behavioral deficits through rearing behavior testing and square bridge testing, and the mean number of SNpc neurons showed significant reduction. There were no behavioral deficits and changes of the mean number of SNpc neurons in rats of NG and VIG. Conclusion Model of Parkinson's disease by rotenone intraperitoneal injection was successfully established. This form of the rotenone model is stable and easy to reproduce, and may provide a new excellent supporter to related studies.