- 著者
- Yuan Ye Xingju Liu
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.41, pp.37-47, 2013-09-30 (Released:2017-06-01)
CD34+ cell is attached with CD34 molecule which is a cluster of differentiation molecule presented on certain cells within the human body. The number of circulating CD34 progenitors has significantly increased in peripheral blood of brain during the fast hematopoietic recovery. CD34+cells can survive, migrate and differentiate towards astrocytes or neurons after transplantation. Moreover, they improve the neurological recovery after cerebral artery occlusion. CD34 molecule is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. This review is about the factors that lead to CD34+ cell proliferation in in-vivo or in-vitro.
- 著者
- Xingju Liu
- 出版者
- Japan Brain Science society
- 雑誌
- 脳科学誌 (ISSN:13415301)
- 巻号頁・発行日
- vol.39, pp.41-50, 2012-10-30 (Released:2017-06-01)
- 参考文献数
- 35
Traumatic brain injury (TBI) results from a sudden and external physical insult to the head, which is associated with a high morbidity and mortality. Current clinical therapy is focused on optimization of the acute/subacute intracerebral milieu, minimizing continued cell death, and subsequent intense rehabilitation to ameliorate the prolonged physical, cognitive, and psychosocial deficits that result from TBI. Given the limited capacity of the central nervous system for self-repair, progenitor (stem) cell therapies have shown promise following TBI in pre-clinical studies and remain a focus of intense scientific investigation. This paper will review some of the progress and barriers involved with stem cell therapies for the treatment of TBI.