著者

大嶽 靖之 Yasuyuki Otake

出版者

学習院大学史学会

雑誌

学習院史学 = Gakushuin historical review (ISSN:02861658)

巻号頁・発行日

no.29, pp.31-53, 1991-03-20

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論説(Article)

著者

Tomoyuki ONISHI Naoko HIROSE Yasuyuki OTAKE Kohki ISHIKAWA Tatsuki KASHIWAGI Kunisuke IZAWA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences: X-ray Structure Analysis Online (ISSN:13482238)

巻号頁・発行日

vol.20, pp.x95-x96, 2004 (Released:2005-02-18)

参考文献数

3

被引用文献数

1

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Both (2S,3S)- and (2R,3S)-N-tert-butoxycarbonyl-3-amino-1-chloro-2-hydroxy-4-phenylbutane (SS- and RS-Boc-ACHPB) are important intermediates of HIV protease inhibitors. Crystals of SS-Boc-ACHPB and RS-Boc-ACHPB are monoclinic P21 and orthorhombic P212121, respectively. The aromatic ring in SS-Boc-ACHPB is placed to avoid repulsive interaction with the hydroxyl group involved in intermolecular hydrogen bonds. On the other hand, the aromatic ring in RS-Boc-ACHPB is situated away from the tert-butoxycarbonylamino group, which is involved in intermolecular hydrophobic interactions with the other aromatic rings. The mode of the intermolecular hydrogen-bonding network is very different for these diastereomers.