著者

YOICHI SHINKAI

出版者

JAPANESE ECONOMIC ASSOCIATION

雑誌

The Economic Studies Quarterly (ISSN:0557109X)

巻号頁・発行日

vol.40, no.1, pp.1-13, 1989-03-20 (Released:2007-10-19)

参考文献数

39

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Although international coordination of macroeconomic policy-making sounds like a way to improve international relations more generally, there is a serious risk that it will have the opposite effect. An emphasis on international interdependence instead of sound domestic policies makes foreign governments the natural scapegoats for any poor economic performance. Pressing a foreign government to alter its domestic economic policies is itself a source of friction and the making of unkeepable promises can only lead to reaentment. It woule in general be far better if the major industrial countries concentrated on the pursuit of sound domestic economic policies and reserved the pursuit of international cooperation for those subjects like international trade and national security in which cooperation is truly essential.M. S. FeldsteinJournal of Economic Perspective, Spring 1988, p. 12

著者

Daisuke Muramatsu Hiroshi Kimura Kaoru Kotoshiba Makoto Tachibana Yoichi Shinkai

出版者

日本細胞生物学会

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

pp.16013, (Released:2016-10-12)

被引用文献数

1 14

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Pericentric regions form epigenetically organized, silent heterochromatin structures that accumulate histone H3 lysine 9 tri-methylation (H3K9me3) and heterochromatin protein 1 (HP1), a methylated H3K9-binding protein. At pericentric regions, Suv39h is the major enzyme that generates H3K9me3. Suv39h also interacts directly with HP1. However, the importance of HP1 interaction for Suv39h-mediated H3K9me3 formation at the pericentromere is not well characterized. To address this question, we introduced HP1 binding-defective, N-terminally truncated mouse Suv39h1 (ΔN) into Suv39h-deficient cells. Pericentric H3K9me3-positive cells were not detected by endogenous-level expression of ΔN. Notably, ΔN could induce pericentric accumulation of H3K9me3 as wild type Suv39h1 did if it was overexpressed. These findings demonstrate that the N-terminal region of Suv39h1, presumably via HP1–Suv39h1 interaction, is required for Suv39h1-mediated pericentric H3K9me3 formation, but can be overridden if Suv39h1 is overproduced, indicating that Suv39h1-mediated heterochromatin formation is controlled by multiple modules, including HP1.