著者

Yoshihiro Miyake Keiko Tanaka Chisato Nagata Hidenori Senba Yasuko Hasebe Toyohisa Miyata Takashi Higaki Eizen Kimura Bunzo Matsuura Ryuichi Kawamoto

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63781, (Released:2022-09-30)

参考文献数

29

被引用文献数

2

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Aim: Epidemiological evidence regarding the relationship between fish and fatty acid intake and carotid intima-media thickness (CIMT) has been limited and inconsistent. The current cross-sectional study investigated this issue using baseline data from the Aidai Cohort Study. Methods: Study subjects were 2024 Japanese men and women aged 34-88 years. Right and left CIMT were measured at the common carotid artery using an automated carotid ultrasonography device. Maximum CIMT was defined as the largest CIMT value in either the left or right common carotid artery. Carotid wall thickening was defined as a maximum CIMT value >1.0 mm. Results: The prevalence of carotid wall thickening was 13.0%. In men, intake of n-3 polyunsaturated fatty acids (PUFA) was independently positively related to the prevalence of carotid wall thickening, while no associations were found between intake of fish and the other fatty acids and carotid wall thickening or maximum CIMT. In women, intake levels of fish, n-3 PUFA, eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid were independently inversely associated with carotid wall thickening and intake levels of fish, n-3 PUFA, α-linolenic acid, n-6 PUFA, and linoleic acid were independently inversely associated with the maximum CIMT. No significant relationships were found between intake of total fat, saturated fatty acids, or monounsaturated fatty acids and carotid wall thickening or maximum CIMT regardless of sex. Conclusions: In women, higher intake of fish and n-3 and n-6 PUFA may be associated with a lower prevalence of carotid wall thickening and a decrease in maximum CIMT.

著者

Yoshihiro Miyake Hideki Tada Masafumi Yano Hiroshi Shimizu

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

vol.19, no.6, pp.363-370, 1994 (Released:2006-03-27)

参考文献数

18

被引用文献数

10 21

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The relationship between intracellular period modulation and external environment change was investigated from the viewpoint of internal information coding in Physarum plasmodium. For the external conditions, concentration changes of attractant (galactose) and repellent (KC1) were used, and the internal responses were measured as the thickness oscillation of the plasmodium. (i) Period of the intracellular oscillation decreased when the concentration of attractant was increased and when the concentration of repellent was decreased, (ii) The period increased when the attractant was decreased and when the repellent was increased, (iii) The larger concentration change induced the larger period modulation, (iv) These responses were observed when the change of concentration was greater than a threshold value. From these results, it was clarified that the relative change in environmental condition is encoded on the relative period modulation in intracellular oscillation. This means that the period change does not directly represent the environment itself but represents the change of its condition. Thus, it is further suggested that the plasmodium estimates the environmental condition based on the relationship between the previous external condition and the present one.

著者

Yoshihiro Miyake Keiko Tanaka Tetsuo Nishikawa Mitsuhide Naruse Ryoichi Takayanagi Hironobu Sasano Yoshiyu Takeda Hirotaka Shibata Masakatsu Sone Fumitoshi Satoh Masanobu Yamada Hajime Ueshiba Takuyuki Katabami Yasumasa Iwasaki Hirotoshi Tanaka Yusuke Tanahashi Shigeru Suzuki Tomonobu Hasegawa Noriyuki Katsumata Toshihiro Tajima Toshihiko Yanase

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ13-0353, (Released:2013-09-28)

被引用文献数

7 36

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The Research Committee of Disorders of Adrenal Hormones, Japan, undertook a nationwide epidemiological study of primary aldosteronism (PA). The present study was undertaken as a part of this study to reveal the relationship between type of treatment and the prognosis of PA. In the primary survey, 4161 patients with PA during the period January 1, 2003-December 31, 2007 were reported from 3252 departments of internal medicine, pediatrics and urology. In the secondary survey, a questionnaire that requested detailed clinical information on individual patients was sent to those departments reporting patients in the primary survey. In total, data on 1706 patients with PA were available in the present study. Among patients with bilateral or unilateral aldosterone-producing adenoma, after adjustment for age at which prognosis was examined, sex, surgical treatment and medical treatment, surgical treatment was significantly associated with amelioration of hypertension (adjusted odds ratio [OR]: 0.47 [95% confidence interval (CI): 0.29–0.77]) and hypokalemia (adjusted OR: 0.17 [95% CI: 0.11–0.29]). No significant relationship was observed between medical treatment and such prognosis in this group of patients. Among patients with bilateral or unilateral adrenal hyperplasia, surgical, but not medical, treatment was significantly associated with amelioration of hypokalemia (adjusted OR: 0.23 [95% CI: 0.06–0.74]), while there was no relationship between surgical or medical treatment and the prognosis of hypertension. In conclusion, surgery offered a better prognosis of PA than medication with regards to hypertension and hypokalemia, with the limitation that a new anti-aldosterone drug, eplerenone, was not available during the study period.

著者

Kentaro MURAKAMI Yoshihiro MIYAKE Satoshi SASAKI Keiko TANAKA Masashi ARAKAWA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.58, no.4, pp.247-252, 2012 (Released:2012-11-07)

参考文献数

33

被引用文献数

8 26

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The possible role of eating rate in promoting obesity has long been of interest. We examined the association between rate of eating and overweight status in Japanese children and adolescents. This Japanese cross-sectional study included 15,974 children (6-11 y; 7,956 boys and 8,018 girls) and 8,202 adolescents (12-15 y; 3,944 boys and 4,258 girls). Rate of eating was self-reported according to five categories. Body mass index (BMI) was calculated from self-reported body weight and height. Overweight was defined according to the International Obesity Task Force age- and sex-specific BMI cutoffs. The overall prevalence of overweight was 13.2%. Rate of eating was positively associated with the risk of overweight, independent of protein, fat, and dietary fiber intakes. Multivariate odds ratios (95% confidence intervals) for overweight in the very slow, relatively slow, medium, relatively fast, and very fast categories were 0.31 (0.20, 0.49), 0.49 (0.40, 0.60), 1 (reference), 2.81 (2.42, 3.26), and 4.49 (3.47, 5.81) in male children; 0.42 (0.31, 0.58), 0.49 (0.41, 0.59), 1 (reference), 2.74 (2.27, 3.31), and 5.69 (3.75, 8.63) in female children; 0.13 (0.03, 0.54), 0.43 (0.28, 0.65), 1 (reference), 2.31 (1.88, 2.84), and 3.84 (2.77, 5.31) in male adolescents; and 0.55 (0.30, 1.01), 0.46 (0.33, 0.65), 1 (reference), 1.30 (0.99, 1.71), and 1.49 (0.84, 2.65) in female adolescents, respectively (all p for trend<0.0001). In conclusion, this large cross-sectional study in Japan showed that a higher rate of eating was independently positively associated with an increasing risk of overweight in children and adolescents.