- 著者
- Hideaki ABE Manabu NATSUMEDA Yu KANEMARU Jun WATANABE Yoshihiro TSUKAMOTO Masayasu OKADA Junichi YOSHIMURA Makoto OISHI Yukihiko FUJII
- 出版者
- The Japan Neurosurgical Society
- 雑誌
- Neurologia medico-chirurgica (ISSN:04708105)
- 巻号頁・発行日
- vol.58, no.7, pp.290-295, 2018 (Released:2018-07-15)
- 参考文献数
- 49
- 被引用文献数
- 8 24
Histone H3 mutations are frequently found in diffuse midline gliomas (DMGs), which include diffuse intrinsic pontine gliomas and thalamic gliomas. These tumors have dismal prognoses. Recent evidence suggests that one reason for the poor prognoses is that O6-methylguanine-DNA methyltransferase (MGMT) promoter frequently lacks methylation in DMGs. This review compares the epigenetic changes brought about by histone mutations to those by isocitrate dehydrogenase-mutant gliomas, which frequently have methylated MGMT promoters and are known to be sensitive to temozolomide.