著者

Shohei Yoshida Tomoaki Nakata Masanao Naya Mitsuru Momose Yasuyo Taniguchi Yoshimitsu Fukushima Masao Moroi Atsutaka Okizaki Akiyoshi Hashimoto Takatoyo Kiko Satoshi Hida Kazuya Takehana Kenichi Nakajima

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0031, (Released:2023-04-28)

参考文献数

25

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Background: Definitions of cardiac sarcoidosis (CS) differ among guidelines. Any systemic histological finding of CS is essential for the diagnosis of CS in the 2014 Heart Rhythm Society statement, but not necessary in the Japanese Circulation Society 2016 guidelines. This study aimed to reveal the differences in outcomes by comparing 2 groups, namely CS patients with or without systemic histologically proven granuloma.Methods and Results: This study retrospectively included 231 consecutive patients with CS. CS with granulomas in ≥1 organs was diagnosed in 131 patients (Group G), whereas CS without any granulomas was diagnosed in the remaining 100 patients (Group NG). Left ventricular ejection fraction (LVEF) was significantly reduced in Group NG compared with Group G (44±13% vs. 50±16%, respectively; P=0.001). However, Kaplan-Meier curves showed that major adverse cardiovascular events (MACE)-free survival outcomes were comparable between the 2 groups (log-rank P=0.167). Univariable analyses showed that significant predictors of MACE were Groups G/NG, histological CS, LVEF, and high B-type natriuretic peptide (BNP) or N-terminal pro BNP concentrations, but none of these was significant in multivariable analyses.Conclusions: Overall risks of MACE were similar between the 2 groups despite different manifestations in cardiac dysfunction. The data not only validate the prognostic value of non-invasive diagnosis of CS, but also show the need for careful observation and therapeutic strategy in patients with CS without any granuloma.

著者

Yoshimitsu Fukushima Kojiro Irikura

出版者

The Seismological Society of Japan, The Volcanological Society of Japan, The Geodetic Society of Japan

雑誌

Journal of Physics of the Earth (ISSN:00223743)

巻号頁・発行日

vol.45, no.2, pp.135-146, 1997 (Released:2009-04-30)

参考文献数

20

被引用文献数

5 6

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The peak horizontal acceleration and velocity of observed records from the 1995 Hyogo-ken Nanbu earthquake are compared with those predicted from empirical attenuation relations that were derived to be applicable to near-source areas. We found that the observed peak values matched well the empirical attenuation relations. The observed peak vertical accelerations were about half the peak horizontal accelerations when less than 100 cm/s/s. But, the observed peak vertical accelerations tended to be more than half the horizontal ones beyond 100 cm/s/s, and at some sites on soft soil, the peak vertical accelerations were greater than the peak horizontal accelerations. On the other hand, most of the observed peak vertical velocities were about 40% of the peak horizontal velocities independent of the peak amplitudes. At Port Island in Kobe City, remarkable non-linear behavior of soft soil was observed in the vertical array records. The high-frequency shear waves decreased due to liquefaction and the peak horizontal accelerations decayed at the surface. On the contrary, vertical ground motion was amplified by the strong contrast of P-wave velocity in the surface soils. This fact may be one of the causes for greater peak vertical acceleration than peak horizontal acceleration.