- 著者
- Sakiko Itaya Zen Kobayashi Kokoro Ozaki Nozomu Sato Yoshiyuki Numasawa Kinya Ishikawa Takanori Yokota Hiroshi Matsuda Shuzo Shintani
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.0068-17, (Released:2018-02-09)
- 参考文献数
- 14
- 被引用文献数
- 4
A 58-year-old man consulted our hospital due to a 2-year history of dysarthria and a 1-month history of blepharospasm. In addition to the ataxic dysarthria and blepharospasm, a neurological examination demonstrated slight ataxia of the trunk and lower limbs. Brain MRI demonstrated atrophy of the upper portion of the cerebellar vermis. Gene analysis established a diagnosis of spinocerebellar ataxia type 31 (SCA31). SPECT with the three-dimensional stereotaxic ROI template (3DSRT) software program demonstrated hyperperfusion in the lenticular nucleus and thalamus. Although the association between SCA31 and blepharospasm in our patient remains unclear, we considered that this combination might be more than coincidental.
- 著者
- Soichiro Suzuki Shotaro Naito Yoshiyuki Numasawa Mizuho Asada Norikazu Shoji Moko Zeniya Daiei Takahashi Hidehiko Sato Soichiro Iimori Naohiro Nomura Eisei Sohara Tomokazu Okado Yasuyoshi Ishiwata Masashi Nagata Tatemitsu Rai Takanori Yokota Shinichi Uchida
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.58, no.12, pp.1775-1779, 2019-06-15 (Released:2019-06-15)
- 参考文献数
- 23
- 被引用文献数
- 23
Encephalopathy is a rare side effect of cephalosporin treatment. We herein present a case of encephalopathy induced by ceftriaxone, a third-generation cephalosporin, in a patient with renal failure. An 86-year-old woman on maintenance hemodialysis received ceftriaxone for Helicobacter cinaedi bacteremia. Her mental status deteriorated during antibiotic treatment, and an electroencephalogram revealed triphasic waves predominantly in the frontal area. Her consciousness improved after the discontinuation of the antibiotic due to the suspicion of ceftriaxone-induced encephalopathy. This is the first reported case of encephalopathy associated with high plasma and cerebrospinal fluid ceftriaxone concentrations, and provides significant evidence for a causal relationship between the administration of ceftriaxone and the onset of encephalopathy.
- 著者
- Miho YOSHIOKA Zen KOBAYASHI Keisuke INOUE Mayumi WATANABE Kaori KATO Kazunori TOYODA Yoshiyuki NUMASAWA Shoichiro ISHIHARA Hiroyuki TOMIMITSU Shuzo SHINTANI
- 出版者
- Japanese Society for Brain Function and Rehabilitation
- 雑誌
- Journal of Rehabilitation Neurosciences (ISSN:24342629)
- 巻号頁・発行日
- vol.19, no.1, pp.33-36, 2019 (Released:2019-10-25)
The Trail Making Test (TMT) is widely used as a measure of attention impairment. The time needed to complete TMT (TMT score) is prolonged in association with attention impairment in patients with brain diseases. Thus far, however, there have been no reports of serial changes in the TMT score after minor ischemic stroke. We retrospectively investigated serial changes in the TMT score of 19 patients with minor ischemic stroke. We included patients in whom TMT could be performed both 4-11 days after onset (initial evaluation) and 14-47 days after onset (second evaluation). The mean value of the initial TMT-A scores was 58 seconds, and that of the initial TMT-B scores was 144 seconds. The mean value of the second TMT-A scores was 43 seconds, and that of the second TMT-B scores was 119 seconds. The TMT-A and TMT-B scores improved in 89 % and 74 % of patients, respectively. This study demonstrated that most minor ischemic stroke patients showed improvement in the TMT score 14 days or later after onset.
- 著者
- Soichiro Suzuki Shotaro Naito Yoshiyuki Numasawa Mizuho Asada Norikazu Shoji Moko Zeniya Daiei Takahashi Hidehiko Sato Soichiro Iimori Naohiro Nomura Eisei Sohara Tomokazu Okado Yasuyoshi Ishiwata Masashi Nagata Tatemitsu Rai Takanori Yokota Shinichi Uchida
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.1785-18, (Released:2019-02-25)
- 参考文献数
- 23
- 被引用文献数
- 23
Encephalopathy is a rare side effect of cephalosporin treatment. We herein present a case of encephalopathy induced by ceftriaxone, a third-generation cephalosporin, in a patient with renal failure. An 86-year-old woman on maintenance hemodialysis received ceftriaxone for Helicobacter cinaedi bacteremia. Her mental status deteriorated during antibiotic treatment, and an electroencephalogram revealed triphasic waves predominantly in the frontal area. Her consciousness improved after the discontinuation of the antibiotic due to the suspicion of ceftriaxone-induced encephalopathy. This is the first reported case of encephalopathy associated with high plasma and cerebrospinal fluid ceftriaxone concentrations, and provides significant evidence for a causal relationship between the administration of ceftriaxone and the onset of encephalopathy.