- 著者
- Keisuke MlKI Mari MlKl Yoichi NAKAMURA Yoshihiro SUZUKI Yoshio OKANO Fumitaka OGUSHI Yuji OHTSUKI Takuro NAKAYAMA
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.42, no.9, pp.839-845, 2003 (Released:2006-03-27)
- 参考文献数
- 29
- 被引用文献数
- 13 19
Although cigarette smoking is a recognized cause of acute eosinophilic pneumonia (AEP), and an increase in eosinophils in the lung is a common occurrence in AEP, early-phase neutrophilia in AEP is not well understood. We describe three cases of cigarette smoke (menthol type)-induced AEP with neutrophilia in the lungs or blood. Increased in-vitro production of the neutrophil chemoattractant interleukin (IL)-8 by human bronchial epithelial cells (HBECs) was correlated with neutrophilia. We suggest that IL-8 released from HBECs is involved in neutrophilia in the lung in AEP, and is newly recognized as an important factor in the early phase of AEP development.(Internal Medicine 42: 839-845, 2003)