著者
Shotaro Ide Noriho Sakamoto Shintaro Hara Atsuko Hara Tomoyuki Kakugawa Yoichi Nakamura Yoji Futsuki Koichi Izumikawa Yuji Ishimatsu Katsunori Yanagihara Hiroshi Mukae
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.56, no.1, pp.79-83, 2017-01-01 (Released:2017-01-01)
参考文献数
20
被引用文献数
1

Although pneumothorax has been reported to be a major pulmonary adverse event in patients treated with pazopanib, a multikinase inhibitor, drug-induced interstitial lung disease (DILD) has not been reported. A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue. He had mild interstitial pneumonia when pazopanib treatment was initiated. Chest computed tomography revealed progressive bilateral ground-glass opacity (GGO) and traction bronchiectasis. We diagnosed DILD due to pazopanib. The patient's pazopanib treatment was interrupted and a steroid was administered. The symptoms and GGO were improved with treatment. Physicians should be aware of DILD due to pazopanib in patients with pre-existing interstitial lung disease.
著者
Yasuhito FUJINO Yoichi NAKAMURA Hideaki MATSUMOTO Kenjiro FUKUSHIMA Masashi TAKAHASHI Koichi OHNO Hajime TSUJIMOTO
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.13-0264, (Released:2013-07-01)
被引用文献数
1 5

A novel hematology analyzer for small animal medicine, ProCyte Dx, was developed from combination of the fluorescence laser flow cytometry and laminar flow impedance technologies, and its accuracy was evaluated by comparing with the conventional impedance-based hematology analyzer, pocH-100iV Diff, or microscopic manual cell counting methods with staining blood smears in the canine blood. Blood samples of 59 dogs were hematologically analyzed and compared by Pearson’s correlation coefficients. Analyses between the two analyzers showed excellent correlation in RBC (r=0.998), HGB (r=0.999), HCT (r=0.998), MCV (r=0.994), MCH (r=0.974), MCHC (r=0.906), WBC (r=0.998) and PLT (r=0.993). Analyses between ProCyte Dx and microscopic manual counting results showed excellent correlation in neutrophils (r=0.920), lymphocytes (r=0.913) and reticulocyte percentages (r=0.924), good correlation in eosinophils (r=0.815) and reticulocyte numbers (r=0.850), and fair correlation in monocytes (r=0.770). The present study indicates that ProCyte Dx is acceptably accurate and can be a powerful tool for canine clinical medicine.
著者
奈良 宏一 仲村 宏一 中村 陽一 山城 迪 Koichi NARA Koichi NAKAMURA Yoichi NAKAMURA Susumu YAMASHIRO
出版者
北見工業大学
雑誌
北見工業大学研究報告 (ISSN:03877035)
巻号頁・発行日
vol.14, no.1, pp.p69-77, 1982-11
被引用文献数
1

In is expected that electrical energy storage facilities will be installed for improving load factor. Although there are no constraints for places to install, ordinarily, a site is considered as a possibility if it is one where transmission loss is minimized or where voltage or frequency can he easily controlled by setting up storage facilities. If storage facilities are installed at load buses, electric power would be maintained by supply from the storage facilities to the loads, even when outage should occur at the power source side of the buses in question. In this paper, the authors propose a method to determine the arrangement of storage facilities, for the objective of minimizing the cost of interruption of electrical service, assuming that the facilities are installed at load buses. The problem is formulated and solved by using the dynamic programming method. From the examples, it is confirmed that we can reduce the cost of interruption by the ratio of (maximum output)/(interrupted load), if the corresponding maximum capacity is 2?5 times larger than the mean outage duration time, and also it is confirmed that it is better to install larger storage facilities for larger capacity loads and for loads with larger mean outage duration time.