著者

Zequn Chen Xuelong Jin

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.40, pp.66-79, 2013-03-30 (Released:2017-06-01)

参考文献数

54

---

Brain radiation therapy is an indispensable therapeutic modality for various primary and metastatic brain tumors and intracranial vascular malformation. With the development of stereotactic radiotherapy, the treatment effectiveness of radiotherapy is obvious; nevertheless, radiation-induced brain injury including both anatomic and functional deficits can not be ignored. Radiation-induced brain injury is a severe sequel after cranial radiation. It can result in a variety of acute, subacute, and delayed clinical syndromes of the brain. The primary changes of vascular endothelial cells, glial cell and neuron in radiation-induced brain injury were reviewed in this paper. In the CNS, single-dose radiation has been shown to result in apoptosis and a 15% loss of endothelial cells within 24 h. Vascular endothelial damage resulted in the change of blood brain barrier permeability. Gial cell damage was related to demyelination and cytokine and inflammatory mediator disorders. Irradiation induced typical apoptotic changes in neurons and affected hippocampal neurogenesis. Understanding the cellular changes may help to develop strategies to either increase the radiation tolerance or to treat CNS alterations induced by irradiation.