著者

Yazhou Cui Quan Xu Jing Luan Shichang Hu Jianbo Pan Jinxiang Han Zhiliang Ji

出版者

バイオ&ソーシャル・サイエンス推進国際研究交流会

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

vol.9, no.3, pp.190-192, 2015 (Released:2015-07-10)

参考文献数

10

被引用文献数

1 5

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Matrix vesicles (MVs) are membranous nanovesicles released by chondrocytes, osteoblasts, and odontoblasts. They play a critical role in modulating mineralization. Here, we present a manually curated database of MV proteins, namely MVsCara to provide comprehensive information on MVs of protein components. In the current version, the database contains 2,713 proteins of six organisms identified in bone, cartilage, tooth tissues, and cells capable of producing a mineralized bone matrix. The MVsCarta database is now freely assessed at http://bioinf.xmu.edu.cn/MVsCarta. The search and browse methods were developed for better retrieval of data. In addition, bioinformatic tools like Gene Ontology (GO) analysis, network visualization and protein-protein interaction analysis were implemented for a functional understanding of MVs components. Similar database hasn't been reported yet. We believe that this free web-based database might serve as a useful repository to elucidate the novel function and regulation of MVs during mineralization, and to stimulate the advancement of MV studies.