著者

野口,範子

出版者

日本運動生理学会事務局

雑誌

日本運動生理学雑誌

巻号頁・発行日

vol.10, no.1, 2003-03-31

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There are increasing reports that the inflammatory responses induced by exercise result in generation of free radicals, reactive oxygen species (ROS), and reactive nitrogen species (RNS). These reactive molecules are known to increase oxidation products and decrease antioxidants resulting in cell damage. The roles of antioxidants in protection of our bodies from ROS-induced oxidative damage have been investigated extensively. The involvement of ROS in gene regulation has been received much attention. It has been reported that exercise induces expression of antioxidant enzymes such as Mn-superoxide dismutase (Mn-SOD) and γ-glutamylcysteine sybthetase (GCS). The regulation of these enzymes is through NF-kB pathway activated by ROSs which were produced in cell due to exercise. In conclusion, acute severe exercise may cause damage but appropriate exercise makes our body resistant against oxidative stress.