著者

Yoshimichi IMAMURA Koichi YOKONO Kozui SHII Joji HARI Hideyo SAKAI Shigeaki BABA

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.23, no.1, pp.3-8, 1984 (Released:2006-03-27)

参考文献数

29

被引用文献数

6 7

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Proinsulin, insulin and C-peptide levels were investigated in chronic renal, hepatic and muscular disorders. The proinsulin levels in human plasma were determined by radioimmunoassay using insulin-degrading enzyme (IDE). The fasting levels of proinsulin in 29 patients with chronic renal failure (0.95±0.05) were significantly higher than those in 10 patients with liver cirrhosis (0.46±0.04), six with muscular dystrophy (0.37±0.02) and 52 normal subjects (0.24±0.02 ng/ml, mean±S.E.). The fasting levels of insulin and C-peptide in chronic renal failure were also the highest amongthese groups. The insulin levels in liver cirrhosis and muscular dystrophy were significantly greater than those in normal subjects and increased molar ratios of proinsulin to total insulin immunoreactivity in chronic renal failure were observed. These results suggest that the kidney, liver and muscle are related to circulating insulin levels and that the kidney plays a particularly important role in circulating proinsulin levels. It can be concluded that increases in these peptides are due to a hypersecretion of B-cells, a decreased degradation or excretion.

著者

SAITOH Makoto HASEGAWA Junichi TAKAMI Tom HOSHIO Akira MIYAKODA Hiroyuki KOTAKE Hiroshi MASHIBA Hiroto TSUTSUMI Sadao KATSUBE Yoshio

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.30, no.4, pp.333-337, 1991

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An 80-year-old man with Ebstein's anomaly and ductus arteriosus aneurysm is reported. He was admitted with bradycardiac atrial fibrillation and right ventricular failure. For the control of brady-arrhythmia, a permanent pacemaker was implanted. Two-dimensional echocardiogram revealed distal displacement of the septal tricuspid valve. Aortography and computed tomography showed ductus arteriosus aneurysm. This is the first report of the association of Ebstein's anomaly and non-patent ductus arteriosus aneurysm.

著者

Akio IKEDA Yasunobu ANTOKU Toshi ABE Hiroshi NISHIMURA Hiroshi IWASHITA

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.28, no.6, pp.740-743, 1989 (Released:2006-03-27)

参考文献数

10

被引用文献数

2 2

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A 62-year-old male Japanese, a heavy drinker for his last 40 years, was admitted to our hospital because of unstable gait of acute onset. Despite large doses of thiamine injection, his condition rapidly worsened with confusion, and died 15 days after the onset. During the deteriorating course, a series of Computerized Tomography (CT) and Magnetic Resonance Imaging (MRI) scans were taken of the brain, which revealed progressive multifocal involvement in the corpus callosum; Marchiafava-Bignami disease was suggested. To the authors' best knowledge, there have been no MRI examinations conducted from so early a stage of this disease on. MRI scanning proves to be a highly useful tool for early diagnosis of Marchiafava-Bignami disease.

著者

Kanji IGA Kenjiro HORI

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.29, no.3, pp.305-308, 1990 (Released:2006-03-27)

参考文献数

6

被引用文献数

3 4

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A case of tetanus accompanied by severe reversible left ventricular motion impairment is reported. Emergent coronary angiography showed no abnormalities and large akinesis was present on left ventriculography. The plasma catecholamine level was not too high in the acute phase, therefore it is thought that the cause of this depressed left ventricular wall motion abnormality was due to some metabolite derived from tetanus.

著者

Shinsuke TAMURA Tetsuhiro KOREEDA Takashi NAKANO Toshikazu HADA Kazuya HIGASHINO

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.29, no.6, pp.611-615, 1990 (Released:2006-03-27)

参考文献数

6

被引用文献数

2 2

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A 53-year-old previously healthy woman suddenly developed adult respiratory distress syndrome (ARDS) of unknown etiology. High-dose corticosteroid pulse therapy and artificial ventilation were started immediately and she dramatically responded to the treatment. However, soon after recovery from ARDS, she developed typical rheumatoid arthritis (RA). Although no apparent relationship between RA and ARDS was clear, this case is quite suggestive in the consideration of the etiology of ARDS.

著者

Osamu RIKITAKE Takanobu SAKEMI Yasuji YOSHIKAWA Yoshiro NAGANO Teruo WATANABE

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.28, no.4, pp.523-526, 1989 (Released:2006-03-27)

参考文献数

21

被引用文献数

9 15

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A 57-year-old woman who had had renal amyloidosis with nephrotic syndrome for five years was found to have the Fanconi syndrome and monoclonal lambda light-chain proteinuria. The amyloidosis of this patient was of primary type on the basis of the permanganate-resistent amyloid, the presence of monoclonal light-chain proteinuria, and the absence of clinical and histologic evidence of multiple myeloma. To best of our knowledge, this is the first case report in which primary amyloidosis with monoclonal lambda light-chain proteinuria was accompanied by adult Fanconi syndrome.

著者

Hideki WAKUI Ikuko TADA Yasunori KIMURA Kosaku YOSHIDA Yasuyuki ENDO Akira B MIURA

出版者

The Japanese Society of Internal Medicine

雑誌

Japanese Journal of Medicine (ISSN:00215120)

巻号頁・発行日

vol.28, no.6, pp.736-739, 1989 (Released:2006-03-27)

参考文献数

11

被引用文献数

1 2

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We report an Rh(D)-negative man with myelodysplastic syndrome who produced six anti-erythrocyte alloantibodies (anti-D, -C, -E, -Dia, -Jka and -S) in succession. Three of these antibodies (anti-E, -Jka and -S) were not noted until delayed hemolytic transfusion reactions occurred. Treatment with cortico-steroids was effective in preventing both further formations of antibodies and other transfusion reactions. It was very difficult to find blood compatible with the patient, but repetitive blood transfusions were required for his progressive anemia and thrombocytopenia. Several problems concerning the transfusion of blood in such a case are discussed.