- 著者
- Shimoda Yoichi Han Junkyu Kawada Kiyokazu Smaoui Abderrazak Isoda Hiroko
- 出版者
- Hindawi
- 雑誌
- Journal of biomedicine and biotechnology (ISSN:11107243)
- 巻号頁・発行日
- vol.2012, pp.428514, 2012
- 被引用文献数
- 6
Energy metabolism is a very important process to improve and maintain health from the point of view of physiology. It is well known that the intracellular ATP production is contributed to energy metabolism in cells. Cistus monspeliensis is widely used as tea, spices, and medical herb; however, it has not been focusing on the activation of energy metabolism. In this study, C. monspeliensis was investigated as the food resources by activation of energy metabolism in human intestinal epithelial cells. C. monspeliensis extract showed high antioxidant ability. In addition, the promotion of metabolites of glycolysis and TCA cycle was induced by C. monspeliensis treatment. These results suggest that C. monspeliensis extract has an ability to enhance the energy metabolism in human intestinal cells.
- 著者
- Kawasaki Aya Ito Ikue Ito Satoshi Hayashi Taichi Goto Daisuke Matsumoto Isao Takasaki Yoshinari Hashimoto Hiroshi Sumida Takayuki Tsuchiya Naoyuki
- 出版者
- Hindawi Publishing
- 雑誌
- Journal of biomedicine and biotechnology (ISSN:11107243)
- 巻号頁・発行日
- vol.2010, pp.207578, 2010
- 被引用文献数
- 27 15
Recent genome-wide association studies demonstrated association of single nucleotide polymorphisms (SNPs) in the TNFAIP3 region at 6q23 with systemic lupus erythematosus (SLE) in European-American populations. In this study, we investigated whether SNPs in the TNFAIP3 region are associated with SLE also in a Japanese population. A case-control association study was performed on the SNPs rs13192841, rs2230926, and rs6922466 in 318 Japanese SLE patients and 444 healthy controls. Association of rs2230926 G allele with SLE was replicated in Japanese (allelic association P=.033, odds ratio [OR] 1.47, recessive model P=.023, OR 8.52). The association was preferentially observed in the SLE patients with nephritis. When the TNFAIP3 mRNA levels of the HapMap samples were examined using GENEVAR database, the presence of TNFAIP3 rs2230926 G allele was associated with lower mRNA expression of TNFAIP3 (P=.013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations.