著者

辻田 賢一 ツジタ ケンイチ Tsujita Kenichi

出版者

熊本大学

巻号頁・発行日

2007-03-27

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Early coronary reperfusion limits myocardial damage and improves survival after acute myocardial infarction (AMI). However, growing evidence indicates that this lifesaving therapeutic approach can cause damage to the previously ischemic myocardium,known as post-ischemic myocardial reperfusion injury. There is now increasing evidence that reactive oxygen species cause reperfusion injury. On the other hand, Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, has been shown to inhibit lipid peroxidation and endothelial cell injury. We examined the effects of edaravone in patients AMI.