著者

手塚 治

出版者

奈良医学会

雑誌

奈良医学雑誌 (ISSN:04695550)

巻号頁・発行日

vol.11, no.5, 1960-10

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博士(医学)・第88号・昭和36年2月7日

著者

手塚 治

出版者

奈良医学会

雑誌

奈良医学雑誌 (ISSN:04695550)

巻号頁・発行日

vol.11, no.5, 1960-10

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The fine structure of the membrane of cell organelles appearing in the atypical spermatid of Cipangopaludina malleata Reeve has been studied in thin sections by an electron microscope.The porous structure has been revealed in the wall of the flattened sacculus consisting the Golgi complex. The walls are calculated 35 A thick. The mitochondria consist of a small number of tubules and an osmiophilic matrix. The mitochondria represent a complex system of tubules projected from the inner layer of the limiting membrane, and the tubules consist of double dense mcmbrans involving a less dense interspace. The mitochondria aggregated along the developing tail filaments coalesce to form an elongated mass of relatively large size. The limiting membrane of the rough-surfaced endoplasmic reticulum appears apparcntly to be a single layer, which makes its appearance in the area where the tail filaments devlop. The smooth surfaced endoplasmic reticulum is bordcrcd by a double layercd membrane consisting two opaque layers with a less opaque interspace. The vesicles containing dense granules, which represent the smooth surfaced endoplasmic reticulum, migrate to the cell periphery. The smooth surfaced endoplasmic reticulum scems to function as an intraccllular conductor.博士(医学)・第88号・昭和36年2月7日

出版者

奈良医学会

雑誌

奈良医学雑誌 (ISSN:04695550)

巻号頁・発行日

vol.44, no.1, pp.1-4, 1993-02-28

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A 29-year-old female was admitted complaints of dyspnea and high fever without therapy for abnormal shadow on chest roentgenogram during 8 months due to her religious problems. Because M. tuberculosis was detected, therapy for tuberculosis was indicated. After this therapy, widespread consolidation with diffuse fine nodular shadows on chest roentgenogram turned to multiple thin walled cavities with wide destruction of lung tissue. This advanced tuberculosis was thought to result mainly from the patient's delay.

出版者

奈良医学会

雑誌

奈良医学雑誌 (ISSN:04695550)

巻号頁・発行日

vol.42, no.6, pp.523-534, 1991-12-31

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The present study was carried out to elucidate the mechanism by which living cells of Salmonella typhimurium confer long-lasting immunity in mice against murine typhoid. Living cells of either virulent or avirulent organisms of S. typhimurium inducedhigher levels of mouse protection of which the duration correlated with the persistence of each bacterium in the liver as a L form. In contrast, S. schottmülleri, of which O antigenicity is identical to that of S. typhimurium, induced only short-term protection, since L forms of the bacteria existed in the liver only over a short period. The capacity of salmonella L forms to persist in the liver was attributable to the ability of salmonella organisms to produce cytotoxin and they changed into L forms. This cytotoxin was toxic only to macrophages and polymorphonuclear leukocytes in vitro. The persistence of L forms in mice resulted in high production of both the tumor necrosis factor and membrane associated interleukin 1 upon challenge with virulent S. typhimurium, which would lead tothe initiation of S. typhimurium-specific immunity. These results suggest that the persistence of salmonella L forms in mice might be required for longer-lasting immunity against murine typhoid after immunization with live-cell vaccines.