著者

Naoyuki Sugano

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.54, no.1, pp.1-5, 2012 (Released:2012-03-30)

参考文献数

24

被引用文献数

4 22

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Despite its important role in the control of periodontal disease, mechanical plaque control is not properly practiced by most individuals. Therefore, adjunctive chemical plaque control using chlorhexidine and antibiotics has also been suggested as an additional therapeutic strategy to augment mechanical plaque control. However, the additional effects of adjunctive antibiotic therapy are small, and topical chlorhexidine therapy is not without side effects. Given current limitations, new approaches for the control of biofilm are required. The new therapeutic approaches discussed in this review are divided into two categories: probiotics and vaccines. Probiotics is an interesting new field of periodontology research that aims to achieve biological plaque control by eliminating pathogenic bacteria. In addition, passive immunization using egg yolk antibody raised against periodontal pathogens may be an effective approach for the treatment of periodontitis. Further study to evaluate the possible effects of these biological plaque control methods against periodontal disease is warranted. (J Oral Sci 54, 1-5, 2012)

著者

Denusa Moreira Veríssimo Mônica Sampaio do Vale

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.48, no.3, pp.93-98, 2006 (Released:2006-10-06)

参考文献数

42

被引用文献数

22 73

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Apical leakage continues to be a topic of great interest, because in spite of the advances in Endodontics, clinical failures still occur. Most failures are probably attributed to the proliferation of bacteria that remain viable after chemical-mechanical preparation and cause periapical tissue irritation. Coronal leakage has aroused researchers’ interest over the last few years, since canals may be re-contaminated after loss of coronal sealing or fracture of the remaining tooth. In this review, the various methodologies used for assessing root canal sealing capacity are critically analyzed, as they are not standardized, which makes it difficult to compare the results obtained when different methodologies are used, even though the same substrate is being assessed. (J. Oral Sci. 48, 93-98, 2006)

著者

Ruchadaporn Kaomongkolgit Kusuma Jamdee Niratcha Chaisomboon

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.51, no.3, pp.401-406, 2009 (Released:2009-09-24)

参考文献数

25

被引用文献数

54 83

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This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 μg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alpha-mangostin was determined and it was found that alpha-mangostin at 4,000 μg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis. (J Oral Sci 51, 401-406, 2009)

著者

Tamaki Yoh Nomura Yoshiaki Takeuchi Hiroaki Ida Hirohisa Arakawa Hirohisa Tsurumoto Akihisa Kumagai Takashi Hanada Nobuhiro

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.48, no.3, pp.111-116, 2006

被引用文献数

7

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The aim of this study was to evaluate the clinical efficacy and safety of a dental drug delivery system (3DS) for the selective reduction of mutans streptococci. Twenty patients with high levels of mutans streptococci in saliva participated. The efficacy of 0.2% chlorhexidine (CHX) delivered by 3DS in reducing the salivary levels of mutans streptococci compared with total streptococci and lactobacilli was investigated. Each subject was treated by professional mechanical tooth cleaning (PMTC) and subsequently individual trays with CHX for 5 min. Salivary bacterial samples were taken at the baseline and weeks 1-12. A significant reduction in the colony count of mutans streptococci was observed during the first 4 weeks compared with the baseline count, while no significant decrease in the count of total streptococci or lactobacilli was found during 12 weeks. In particular, the proportion of mutans streptococci in total streptococci remained low after 12 weeks. Our results indicate that the new 3DS used in combination with PMTC appears to be a promising intraoral drug delivery system which, when used with a low CHX concentration selectively, effectively reduces mutans streptococci in the oral cavity with no adverse effects. (J. Oral Sci. 48, 111-116, 2006)

著者

Ataollah Habibi Nasrollah Saghravanian Mehdi Habibi Ehsan Mellati Morteza Habibi

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.49, no.3, pp.229-235, 2007 (Released:2007-10-09)

参考文献数

39

被引用文献数

38 72

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A retrospective analysis was conducted on patients diagnosed with and treated for keratocystic odontogenic tumor (KCOT) at Mashhad School of Dentistry between 1996 and 2006. The patients comprised 44 men and 30 women with a mean age of 27.08 years. Among the total of 83 lesions, 56 (67.5%) occurred in the mandible and 27 (32.5%) in the maxilla. Swelling tended to be the most common complaint (45.8%), while 24.1% of the lesions were diagnosed incidentally. Six patients (8.1%) with a total of 15 lesions had nevoid basal cell carcinoma syndrome; 28 lesions (33.7%) were associated with an impacted tooth, and 12 (14.5%) presented daughter cysts. Sixty-six KCOTs were treated by enucleation [5 recurrences (7.6%)], 6 by marsupialization [2 recurrences (33.3%)] and 11 by marsupialization followed by enucleation (no recurrences). KCOTs in the mandible showed a higher recurrence rate than those in the maxilla (10.7% vs 3.7%). Although the demographics of Iranian patients are closely similar to those of other nationalities, in this series KCOTs tended to develop in younger patients with a peak in teenagers. The posterior region of the mandible showed the highest likelihood of KCOT occurrence and recurrence. Marsupialization followed by enucleation resulted in the lowest recurrence rate. (J. Oral Sci. 49, 229-235, 2007)

著者

Hidero Ohki Mitsuhiko Matsumoto Mitsuharu Hasegawa Osamu Shimizu Shotaro Mukae Yusuke Amano Kazuo Komiyama

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.47, no.4, pp.219-222, 2005 (Released:2006-01-17)

参考文献数

8

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A 54-year-old male presented with the complaint of a painful sore on the left side of his tongue. Our examination found an ulcer 15 × 20 mm in size on the left edge of the tongue, with peripheral indurations. The lesion was diagnosed histopathologically as squamous cell carcinoma (T2N0M0). Consequently, the lesion was surgical removed and radical neck dissection was performed. Four months after the operation, two unusual cyst-like lesions were identified in the parapharyngeal space by CT and MRI. A biopsy specimen revealed recurrent carcinoma with a cyst-like structure. The route of the tumor metastasis into the parapharyngeal space was obscured, but it was speculated that the excessive lymph accumulation was due to a lymphatic occlusion caused by the surgical procedure, proliferation of the metastatic carcinoma, or stagnation and accumulation of tissue fluid caused by parapharyngeal invasion by the recurrent lesion. (J. Oral Sci. 47, 219-222, 2005)