著者

馬場 嘉信

出版者

Division of Chemical Information and Computer Sciences, The Chemical Society of Japan/Division of Structure -Activity Studies, The Pharmaceutical Society of Japan

雑誌

情報化学討論会・構造活性相関シンポジウム講演要旨集

巻号頁・発行日

pp.K20, 2001 (Released:2001-10-24)

参考文献数

14

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Since human genome sequencing has been almost completed, human genome project will quickly move on to the post genome sequencing era towards the future personalized medicine. Capillary array electrophoresis with 96-384 capillaries plays a vital role in the genome sequencing era and the eight to nine order increase in DNA sequencing efficiency was achieved during last three decades. But in the post genome sequencing era, further development of analytical technology for DNA, mRNA, protein, and metabolites is highly required. Such drastic improvement in speed and cost for sequencing requires aggressive technological innovation fuelled by major investment. Improvements are needed to move current dideoxy sequencing to smaller volumes and more rapid sequencing times, based upon advances such as microchannel electrophoresis. More revolutionary methods, such as mass spectrometry (MS) and nanotechnology including single-molecule sequencing and nanopore approaches, have note been fully developed, but hold great promise and deserve strong encouragement. The microchip-based technology will be a key technology in the post-genome sequencing era, since even revolutionary methods as well as microchannel electrophoresis will be able to develop on a chip. Recent progress in microfabrication and nanofabrication technologies based on computer chip technique induces the new research area for integrated microchip and nanochip technology. Investigation of integrated microchip technology is developing towards the integration for whole steps required for the personalized medicine.