著者

Hashimoto Keiichi HIROSE Masaru FURUKAWA Soichi HAYAKAWA Hirokazu KIMURA Eiichi

出版者

International Heart Journal刊行会

雑誌

Japanese Heart Journal (ISSN:00214868)

巻号頁・発行日

vol.18, no.5, pp.679-689, 1977

被引用文献数

1 47

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The following parameters were studied before and after acute occlusion of the anterior descending branch of the left coronary artery in 17 dogs: bradykinin (BK) in the coronary sinus blood, heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular max dp/dt (LV max dp/dt), and an index of myocardial contractility (LV max dp/dt/IP).<br>BK levels increased, reaching a maximum of 30&plusmn;13ng/ml 2 min after coronary ligation, accompanied by a significant elevation of LVEDP, and lowering of the myocardial contractility index. HR and LV max dp/dt showed no significant changes. A positive correlation obtained between the level of BK and LVEDP, as well as a negative correlation be-tween the level of BK and of both LVSP and myocardial contractility in-dex. Pretreatment with aprotinine (Trasylol), an inhibitor of kinin forming enzyme, prevented the increase in both BK and LVEDP after coronary artery ligation and caused an elevation of myocardial contractility index. These results suggest that BK formed within ischemic myocardium exerts a negative inotropic action on the heart.

著者

Chang Sonia ROBERTS Susan CHANG John K. KLEINBERG Martha RODRIQUEZTORRES Ramon

出版者

International Heart Journal刊行会

雑誌

Japanese Heart Journal (ISSN:00214868)

巻号頁・発行日

vol.20, no.3, pp.289-299, 1979

被引用文献数

1

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Right ventricular wall motion was readily accessible for echocardiographic recording along the right sternal border in 27 pediatric patients (age: 24hrs-12yrs). Right ventricular epicardial and endocardial wall motion could be recorded only at the right sternal border in 10 of these patients, emphasizing the need for a new, alternative examination site.<br>Calculated measurements of right ventricular wall thickness recorded from both right and left sternal borders (7pts) were similar (range of diff.=0-0.6mm; mean of dill.=0.26mm). Autopsy confirmation of right ventricular wall thickness was obtained in 2 patients.Epicardial motion could not be identified at the left sternal border in 10 patients. In these patients, right ventricular wall thickness was estimated by measuring from the inner chest wall to the endocardium. These measurements were compared to right ventricular wall thickness obtained from the right sternal border. Wall thickness obtained from the left sternal border was significantly underestimated in the absence of a definite epicardial interface (range of diff.=0.2-2.6mm; mean of diff.=1.3mm).<br>We conclude that the right sternal border is a useful examination site when studies from the left sternal border are technically inadequate for evaluation. Measurement of right ventricular wall thickness should not be attempted unless both epicardial and endocardial interfaces are recorded simultaneously.