著者

篠原 彰

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.47, no.2, pp.100-106, 2007 (Released:2007-03-31)

参考文献数

14

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Homologous recombination promotes faithful segregation of homologous chromosomes during meiosis. Two RecA homologues, Rad51 and Dmc1, work together to catalyze homology search and strand exchange process in the recombination. We recently identified a protein complex containing two meiosis-specific proteins, Mei5 and Sae3, which promotes the assembly of Dmc1 on the Rad51 ensembles. In this review, I will discuss the function of Dmc1-containing protein machinery in meiotic-recombination and possible asymmetric distribution of the two RecA homologues on chromosomes.