著者
Ken Nishikawa Akira R. Kinjo
出版者
日本生物物理学会
雑誌
BIOPHYSICS (ISSN:13492942)
巻号頁・発行日
vol.10, pp.99-108, 2014 (Released:2014-12-17)
参考文献数
50
被引用文献数
1 8

We propose the cooperative model of phenotype-driven evolution, in which natural selection operates on a phenotype caused by both genetic and epigenetic factors. The conventional theory of evolutionary synthesis assumes that a phenotypic value (P) is the sum of genotypic value (G) and environmental deviation (E), P=G+E, where E is the fluctuations of the phenotype among individuals in the absence of environmental changes. In contrast, the cooperative model assumes that an evolution is triggered by an environmental change and individuals respond to the change by phenotypic plasticity (epigenetic changes). The phenotypic plasticity, while essentially qualitative, is denoted by a quantitative value F which is modeled as a normal random variable like E, but with a much larger variance. Thus, the fundamental equation of the cooperative model is given as P=G+F where F includes the effect of E. Computer simulations using a genetic algorithm demonstrated that the cooperative model realized much faster evolution than the evolutionary synthesis. This accelerated evolution was found to be due to the cumulative evolution made possible by a ratchet mechanism due to the epigenetic contribution to the phenotypic value. The cooperative model can well account for the phenomenon of genetic assimilation, which, in turn, suggests the mechanism of cumulative selection. The cooperative model may also serve as a theoretical basis to understand various ideas and phenomena of the phenotypedriven evolution such as genetic assimilation, the theory of facilitated phenotypic variation, and epigenetic inheritance over generations.

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獲得形質の進化への寄与を示唆。生物が積極的に表現型のゆらぎを大きくする,と想定すると,表現型のゆらぎが大きいもの,また遺伝型の適応度が高いものが生き残るラッチェット機構が実現される。獲得形質が遺伝型に置き換わる進化過程も再現。N.K https://t.co/agRvqn26zz
【学会ニュース更新】欧文誌[BIOPHYSICS]に論文が新規掲載されました。(遺伝子変異と表現型可塑性の共同作用で表現型の進化が加速する)https://t.co/hLgsQ1N0ei

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