著者
Lucia Renee Ruhaak Jenny Felth Pernilla Christina Karlsson Joseph James Rafter Robert Verpoorte Lars Bohlin
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.34, no.5, pp.774-778, 2011-05-01 (Released:2011-05-01)
参考文献数
35
被引用文献数
23 57

Cyclooxygenase enzymes (COX-1 and COX-2) catalyse the production of prostaglandins from arachidonic acid. Prostaglandins are important mediators in the inflammatory process and their production can be reduced by COX-inhibitors. Endocannabinoids, endogenous analogues of the plant derived cannabinoids, occur normally in the human body. The Endocannabinoids are structurally similar to arachidonic acid and have been suggested to interfere with the inflammatory process. They have also been shown to inhibit cancer cell proliferation. Anti-inflammatory effects of cannabinoids and endocannabinoids have been observed, however the mode of action is not yet clarified. Anti-inflammatory activity (i.e., inhibition of COX-2) is proposed to play an important role in the development of colon cancer, which makes this subject interesting to study further. In the present work, the six cannabinoids tetrahydrocannabinol (Δ9-THC), tetrahydrocannabinolic acid (Δ9-THC-A), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA), isolated from Cannabis sativa, were evaluated for their effects on prostaglandin production. For this purpose an in vitro enzyme based COX-1/COX-2 inhibition assay and a cell based prostaglandin production radioimmunoassay were used. Cannabinoids inhibited cyclooxygenase enzyme activity with IC50 values ranging from 1.7·10−3 to 2.0·10−4 M.

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外部データベース (DOI)

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I hate America Pharmaceutical Industry #COVID19 #SARSCoV2 550 nutrients are in #Cannabis forbidden for us to eat since 1915 #JimCrow Cannabinoids operates Immune System ~ God created Cannabis as our food not a drug https://t.co/X2bVqSQGDY https://t.co/YO3qFn9E8l https://t.co/bd6N7Rmc3k https://t.co/LH62bKiJjy
550 nutrients in #Cannabis Eat them God heals us w/ seed bearing herb He said for us to eat as Meat ~ https://t.co/YO3qFn9E8l https://t.co/zLBQJp731G
6 of 550 nutrients in #Cannabis are anti-inflammatory ~ Eat for Immunity ~ Extract and cap for Nutritional Supplement ~ J-STAGE Articles - Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from <i>Cannabis sativa</i> https://t.co/w8LLUFNY2B
Anti-inflammatory properties for treatment of arthritis and lupus https://t.co/68D1cc33lh Neuroprotective properties for treatment of neurodegenerative diseases https://t.co/asmKM41Ax7 https://t.co/bPAf9RNny2
@AlexTheChemist @drmikehart But. "except from CBDA, which only inhibited COX-1. This finding is contradictory to previously reported results by Takeda et al., where CBDA was found to be a selective COX-2 inhibitor" https://t.co/ZI9aclzFTD
@mandymcknight @melrollingstone https://t.co/0eTOr6iIvf https://t.co/917XPSnLEX https://t.co/zRJzJJKGwo
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from <i>Cannabis sativa</i> https://t.co/lhvhBbw92k
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from... http://t.co/ZKlV4XW2NB
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa:... http://t.co/yEL39bCQsS

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