著者
Fan Zhang Mu-rong Liu Hai-tong Wan
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.37, no.3, pp.335-339, 2014-03-01 (Released:2014-03-01)
参考文献数
72
被引用文献数
63 70

PEGylation changes the physical and chemical properties of the biomedical molecule, such as its conformation, electrostatic binding, and hydrophobicity, and results in an improvement in the pharmacokinetic behavior of the drug, while it also causes some disadvantages of which cannot be neglected. The available data manifests that polyethylene glycol (PEG) itself shows potential risk, such as immunogenicity of the PEG and PEG-containing vacuoles in cells observed with PEGylated biologicals. Decreased activity and heterogeneity are also the negative aspects of PEGylation. The unfavorable impacts which are brought by the PEGylation are described here with examples of modified therapeutic proteins on the market and used in the clinical trials.

言及状況

外部データベース (DOI)

Twitter (4 users, 4 posts, 2 favorites)

@StrangerJosh11 https://t.co/ktcFLr0T2k
Cualquier cosa menos investigar si el aumento de mortalidad por todas las causas es mayor en la población vacunada. Cualquier cosa menos estudiar la cinética y eventual acumulación de coadyuvantes peligrosos como PEG https://t.co/e5OVqNA9Hg o Twin80 https://t.co/7wta16yzk5 https://t.co/MbFLriPfZk

収集済み URL リスト