著者
Yi Su Yun Ling Yuyan Ma Lili Tao Qing Miao Qingfeng Shi Jue Pan Hongzhou Lu Bijie Hu
出版者
International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌
BioScience Trends (ISSN:18817815)
巻号頁・発行日
pp.2020.03340, (Released:2020-12-18)
参考文献数
22
被引用文献数
1

The aim of this study is to assess the efficacy of multiple treatments, especially hydroxychloroquine, used in different disease stages of coronavirus disease 2019 (COVID-19). All consecutive patients with COVID-19 admitted to Shanghai Public Health Clinical Center (Shanghai, China) between January 20, 2020, and April 30, 2020, were enrolled, and their clinical data were retrospectively collected. Binary logistic regression was used to screen the factors associated with disease aggravation, and multivariable analyses with the Cox proportional hazards model were used to estimate the effects of prognostic factors on the improvement time and PCR conversion days in throat swabs and stool swabs. A total of 616 patients, including 50 (8.11%) severe and 18 (2.92%) critical patients, were enrolled in our retrospective cohort study. The early use of hydroxychloroquine was a protective factor associated with disease aggravation (95% CI: 0.040-0.575, p = 0.006). Clinical improvement by 20 days was significantly different between patients with hydroxychloroquine used early and those with hydroxychloroquine not used (p = 0.016, 95% CI: 1.052-1.647). The median time to clinical improvement was 6 days in the hydroxychloroquine used early group, compared with 9 days in the without hydroxychloroquine used group and 8 days in the with hydroxychloroquine not used early group (p < 0.001). Hydroxychloroquine used early was associated with earlier PCR conversion in both throat swabs (HR = 1.558, p = 0.001) and stool swabs (HR = 1.400, p = 0.028). The use of hydroxychloroquine at an early stage is a potential therapeutic strategy for treating patients before irreversible severe respiratory complications occur. The early use of hydroxychloroquine decreased the improvement time and the duration of COVID-19 detection in throat and stool swabs.

言及状況

外部データベース (DOI)

Twitter (134 users, 160 posts, 271 favorites)

@kalynka @MilaDaffre @TheInterceptBr https://t.co/ItHyL1eoiz
La référence utilisée pour soutenir l’importance de la précocité du traitement ne donne aucune information sur l’assignation des patients entre groupe contrôle et traitement. Il est donc impossible d’en tirer les conclusions que les auteurs tirent. https://t.co/Zn48BcvAck
@brunbazzo @EliVieiraJr @Rconstantino Exemplos: https://t.co/NMpeUcogwp https://t.co/TvEweviJoM https://t.co/HZHNjb13YH https://t.co/Cb1HnjGQFS https://t.co/loymBSV8AN etc, etc, etc....
@super_venere @Alyssia30239950 @dr_l_alexandre @raoult_didier @Folk89911323 un avis très tranché... mais rien d'autre... du vent... Il faut vraiment se croire très balaise pour donner ce type d'avis, sans rien d'autre. en voici une autre... https://t.co/qRG92zll2W
@rafaeellamrr Leia o estudo, ué! Tá com preguiça de usar océrebro? Aqui vão mais alguns: https://t.co/fsU1jRiBh2 https://t.co/fsU1jRiBh2 https://t.co/fsU1jRiBh2 https://t.co/Q8a3tjP9He https://t.co/1R1u0BpPcK Isso são só alguns aleatórios. Divirta-se.
@romlfrd @frenchieinlimbo @Dadoo5152 @f_philippot Oui je me suis mal exprimé. Cette étude montre une bonne efficacité en traitement précoce, je en sais pas si elle vous donne accès au pdf en anglais https://t.co/Jh4net7NVf
@provaxtexan @KaraQBell1 @fox7austin @MeaEscott @GovAbbott @ltisdschools HCQ when used as "Early Treatment" reduced disease progression by 84.9% https://t.co/c8vcisBcGE
@SudRadio @JeanYvesCAPO @dupontaignan @olivierveran https://t.co/AEd67xRbMa
https://t.co/fOf3uIPePj the early use of HCQ was... found to prevent the progression of the disease aggravation from mild and moderate to severe and critical. The use of HCQ at an early stage is a potentially life-saving therapeutic strategy both to treat and cure patients... https://t.co/vOfyGAvt2K
@fakemedecine https://t.co/AEd67xRbMa
@joaoamoedonovo "sem eficácia comprovada" Você leu os artigos científicos?? https://t.co/fvbBZ8e9az https://t.co/Be1hy47sFG https://t.co/b4mclFwR1c https://t.co/pk7IuYV0lc https://t.co/CzY6eJJGXi
@Fakinho_ @Souvaleria @slpng_giants_pt @TwitterSeguro @TwitterBrasil https://t.co/87j54gUv20
@dadourado Médico negacionista. https://t.co/beulXfoPUJ
@dadourado @PRRibeiro NOSSA VELHA SENHORA HIDROXICLOROQUINA! Salvando vidas sim! Manda pra quem quer estudos...mesmo sem saber ler o que vive pedindo! Fresquinho de 18/12/20!!! https://t.co/OGiX7pg36m
@PaganLuana @delucca Os estudos têm mostrado a eficácia no tratamento PRECOCE, e não tardio. Há vários estudos aí. Você nem se atentou a isso. Não reduz a carga viral, mas dificulta a multiplicação viral. https://t.co/T1kvSaF87N https://t.co/KXYNZIXobs https://t.co/gNVol4PVBK https://t.co/1dvGZQsSyI
@MarceloFreixo NOSSA VELHA SENHORA HIDROXICLOROQUINA! Salvando vidas sim! Manda pra quem quer estudos...mesmo sem saber ler o que vive pedindo! Fresquinho de 18/12/20!!! https://t.co/OGiX7pg36m
@Ri_cardo_franca @EuAnaGabi @mylifesux32 @thyagoamaro @Jpg_netto @VictorSouza1993 @whindersson Deixa eu te ensinar: https://t.co/0mDstNIYe9 abre o estudo, vai em Source e voala! https://t.co/2zV9L1w1Qj Ele te leva a varios portais de medicia onde publicam artigos cientificos, são centenas! Uhuuul que legal! Agora boa leitura pra vc :D https://t.co/7ge2nR91O5
@MarcusV43386868 @JosuePatriota @nikolas_dm Toma, retardado: https://t.co/KTl9T76wMG The early use of hydroxychloroquine decreased the improvement time and the duration of COVID-19 detection in throat and stool swabs.
@LuVillafranca @SilmaradeCarva9 @AlessandroLoio2 https://t.co/lghBV590BF https://t.co/oKYzLr5mSO https://t.co/CpDYlonbHq Boa leitura! Na verdade, hoje temos 164 artigos científicos revisados por pares publicados em periódicos científicos sobre o uso da hidroxicloroquina. Tem bastante.
@QueeeentinM @MLP_officiel https://t.co/1INzYIHJmo
@ThaisMartinsDev @minsaude https://t.co/b2o321ZhDK mais um estudo publicado
@Mateusdecastr15 @hoc111 Não mesmo, nenhuma evidência? É consenso? https://t.co/AVdfCYTtN5
@raoult_didier https://t.co/xr5pBETEKA
@raquelrst @raoult_didier @veramagalhaes @TaschnerNatalia @Estadao @JornalOGlobo NOSSA VELHA SENHORA HIDROXICLOROQUINA! Salvando vidas sim! Manda pra quem quer estudos...mesmo sem saber ler o que vive pedindo! Fresquinho de 18/12/20!!! https://t.co/OGiX7pg36m
Viva nossa velha senhora HIDROXICLOROQUINA, salvando vidas! Mande a seu amigo que gosta de pedir “estudos”, mesmo sem saber ler... https://t.co/OGiX7pg36m
@SvioGuilherme6 @vittxn @luanafIorencio @g1 @GadoDecider https://t.co/yDnxsAXiCa https://t.co/hfMbFXn90h https://t.co/87j54gUv20
@neidialvasc @rafaelcapanema https://t.co/aNLg9ZdUj5
@shepherdsdelig @AlikaRito Strange. Link works for me. Try this for pdf. https://t.co/rReFeQ2bTk https://t.co/kRREzczuRe
@AlikaRito These are AGREGGATING websites. Every individual study is linked to. For example: Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China https://t.co/K624XGMfMD
@avantebrasil @nise_dra HCQ https://t.co/Pq0idbmgZH https://t.co/B0gAtWcYzp
@nise_dra https://t.co/Pq0idbmgZH
Wyong Labor Emma McBride Shadow Health Minister Bagged out Hydroxychloroquine: https://t.co/kxqHKuGD6u C-Virus, Did we have the cure or preventative all along Hmm? BUT: 1 https://t.co/RHKdJh03pZ... 2 https://t.co/ejVn73lFDG https://t.co/2oKh88Dubu
@abcnews C-Virus, Did we have the cure or preventative all along Hmm? Labor VIC banned the use of Hydroxychloroquine Labor Anthony Albanese Shadow Health Minister Bagged out Hydroxychloroquine: https://t.co/kxqHKuGD6u BUT: 1 https://t.co/RHKdJh03pZ... 2 https://t.co/ejVn73lFDG https://t.co/8GigFnhyFQ
China is using Hydroxychloroquine as their treatment for Covid-19! Amazing! What fools we Westerners are!!!! https://t.co/3jSylbvYK3
Anthony Albanese Shadow Health Minister Bagged out Hydroxychloroquine: billsparow1 Twitter The Government of the Indian State of West Bengal (population 91 million) has both Hydroxychloroquine https://t.co/RHKdJh03pZ... 2 https://t.co/ejVn73lFDG https://t.co/WRFktGrt0d
Labor VIC banned the use Hydroxychloroquine: BillSparow1 Twitter The Government of the Indian State of West Bengal Hydroxychloroquine https://t.co/RHKdJh03pZ... 2 https://t.co/ejVn73lFDG https://t.co/j5mCVpunR0
@clicjf Dernier article important en date Su et al., BioScience Trends, doi:10.5582/bst.2020.03340 (Peer Reviewed) Retrospective 616 patients in China https://t.co/NehcfihWk0
@RSGuilland @ninacreder @slpng_giants_pt Artigo Publicado em 18 de Dezembro, sobre eficácia do uso da hidroxicloroquina no tratamento da Covid-19 Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China https://t.co/qA2l4D1mNi https://t.co/kOc8lXvmNY
@CagliostroNd @lebon80 @Olivier87538756 @axelkahn Etude chinoise qui a comparé le traitement précoce versus placébo et tardif. https://t.co/gPLqHtfx09 https://t.co/YRUcfFr8js
And third: Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China. https://t.co/AnG9jYx3JJ
Efficacy of early #HydroxyChloroquine treatment in preventing #COVID19 pneumonia aggravation, the experience from Shanghai, #China The median time to clinical improvement: - 6 days, HCQ used early group - 8 days, HCQ not used early group - 9 days, no HCQ https://t.co/I7Qgghq4gE https://t.co/sdvtwigxSl
HCQ ÉTUDE SHANGAI The early use of hydroxychloroquine was the only factor that markedly reduced the improvement time (p = 0.016) compared with other treatments used early https://t.co/e83L5Wwaim https://t.co/6rYgDVoTOZ
The use of #hydroxychloroquine at an early stage is a potential therapeutic strategy for treating patients before irreversible severe respiratory complications occur. It decreased the improvement time and the duration of COVID-19 detection. #hcqworks https://t.co/SG3vJCocs6
The only -and thus critical- study comparing directly early and late symptomatic treatment of Covid-19 with hydroxychloroquine reveals a narrow therapeutic window. Hence the inconsistent clinical trials' results. HCQ must be used early to be effective. https://t.co/4EfgD3dGSb https://t.co/iGXVHm93q8
Very few studies focus on early hydroxychloroquine use. One from Shangai (n=616) with multiple strong benefit signals: disease progression and earlier PCR conversion, all statistically significant. https://t.co/4EfgD3dGSb https://t.co/MPJDb7uJ4I
Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the... - https://t.co/dLT2Cie6FZ #ScholarAlerts
Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the... - https://t.co/dLT2Cie6FZ #ScholarAlerts

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