著者
Akira Otaka
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.70, no.11, pp.748-764, 2022-11-01 (Released:2022-11-01)
参考文献数
111

Diverse naturally occurring events relevant to proteins, including processing and post-translational modification, provide significant clues enabling advances in peptide/protein chemistry. Our motivation to synthesize large proteins prompted us to seek scientific bases utilized in synthetic experiments on the intein-mediated protein processing system. This account describes peptide/protein thioester-producing protocols whose design is based on acyl transfer reactions observed in the intein system, and the development of the stimulus-responsive amide cleavage and its application to the modulation of peptide function. Finally, several findings derived from nature-inspired research efforts, including peptide mimetic synthesis and S-protected cysteine chemistry, are described.

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大髙教授が執筆されましたreviewがChem. Pharm. Bull. 誌に掲載されました。是非、ご一読下さい。 J-STAGE Articles - Development of Naturally Inspired Peptide and Protein Chemistry https://t.co/a23VOdlNl2 https://t.co/YC6YsiMily

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